摘要
目的大量研究显示非对称性二甲基精氨酸和细胞间粘附分子是内皮功能不全的标志因子,而内皮损害程度和严重冠状动脉狭窄患者侧支循环形成密切相关。本实验旨在检测冠状动脉严重狭窄的冠心病患者血清非对称性二甲基精氨酸和细胞间粘附分子1水平,探讨非对称性二甲基精氨酸和细胞间粘附分子1水平与冠状动脉侧支循环形成程度的相关性。方法收集2005年6月至10月在我院行冠状动脉造影,三支主要冠状动脉中至少有一支冠状动脉狭窄在95%以上的85例冠心病患者,测定其血清非对称性二甲基精氨酸和细胞间粘附分子浓度。采用Rentrop方法对冠状动脉侧支循环进行分级,0～1级为侧支循环形成不良组(n=50),2～3级为侧支循环形成良好组(n=35)。结果侧支循环形成不良组血清非对称性二甲基精氨酸浓度(2.23±0.59μmolL)明显高于侧支循环形成良好组(1.79±0.57μmolL)(P=0.001);侧支循环形成不良组血清细胞间粘附分子1浓度(272.4±68.3μgL)显著高于侧支循环形成良好组(225.0±61.9μgL)(P=0.002)。结论冠状动脉严重狭窄患者冠状动脉侧支循环形成不良与高非对称性二甲基精氨酸和细胞间粘附分子1水平有关。
Aim There is a growing evidence showing that asymmetric dimethylarginine （ADMA） and intercellular adhesion molecule- 1 （ICAM- 1 ） are markers of endothelial dysfunction and the degree of coronary collateral circulation in subjects with severe coronary artery stenosis is attributed to endothelial injury. In the present study, we examined the serum levels of ADMA and ICAM-1 in patients with severe coronary artery stenosis and furthermore to investigate the correlation between the serum levels of ADMA and ICAM-1 with the degree of coronary collateral circulation. Methods 85 patients at least with the stenosis of one vessel 〉 95 % among three main vessels of coronary artery were consecutively enroUed in the study according to anglographic estimation in our hospital from June to November in 2005. Development of collaterals was classified by Rentrop＇ s method. According to the collateral degree, patients were divided into two groups （ poorly developed collateral group： 50 patients with grade 0 and 1 ; well-developed collateral group： 35 patients with grade 2 and 3）. The levels of ADMA and ICAM- 1 were also determined. Results Compared with patients with poorly developed collateral group, the levels of ADMA of patients with well developed collateral group were significantly decreased （2.23±0.59μmol/L vs 1.79±0.57 μmol/L, P=0.001）. Simlarly, the levels of ICAM-1 were also markedly reduced （272.4 ± 68.3 μg/L vs 225.0 ± 61.9 μg/L, P = 0.（D2 ）. Conclusions the present data suggest that poor collateral circulation is related to elevated levels of ADMA and ICAM-1 in patients with severe coronary artery stenosis.
出处
《中国动脉硬化杂志》
CAS
CSCD
2006年第5期441-443,共3页
Chinese Journal of Arteriosclerosis
