摘要
目的通过荟萃分析比较手术与非手术治疗对早期重症急性胰腺炎（SAP）患者的治疗效果.方法根据纳入标准,摘录5篇RCT文献中有关试验设计、研究对象的特征、研究结果等内容,用RevMan4.2软件进行分析.结果 SAP早期手术治疗与非手术治疗效果有显著差异：前者病死率（RR=3.42,95%CI为1.81～6.47,P=0.0002）及并发症发生率高（RR=3.16,95%CI为2.15～4.64,P〈0.00001）,而治愈率低（RR=0.83,95%CI为0.75～0.92,P=0.0005）.结论对SAP早期患者应首选非手术作为常规治疗,而不支持手术治疗.
Objective To analyze and compare the effect of early surgical treatment and nonsurgical treatment for patients with severe acute pancreatitis. Methods Acccording to the including criteria, five randomized controlled trials of this topic were enrolled into the analysis. The detail about the trial design, characters of the subjects, results of the studies were reviewed and analysed by using Revman 4. 2 software. Results Compared with nonsurgical treatment, early surgical treatment was associated with a significantly higher incidence of mortality （ RR 3.42, 95% CI 1.81 -6.47, P =0. 0002） and complications （ RR 3. 16, 95% CI 2. 15 ±4.64, P 〈0.00001）, and with a lower cure rate （RR 0. 83, 95% CI 0.75 - 0.92, P = 0. 0005 ）. Conclusions The findings suggest that for early severe acute pancreatitis, non-operative management should be selected routinely as the first choice of treatment and do not support operative treatment.
出处
《中国普通外科杂志》
CAS
CSCD
2006年第6期455-459,共5页
China Journal of General Surgery
