摘要
目的研究胃癌患者癌组织中EB病毒(Epstein-Barrvirus,EBV)感染与c-erbB-2表达的关系。方法原位杂交法检测胃癌患者石蜡标本中EBV编码的小RNA(EBER1);免疫组化法检测EBV阳性胃癌(EBVaGC)及EBV阴性胃癌(EB-VnGC)标本C-erbB-2蛋白的表达状况。结果217例胃癌患者癌组织标本中检测到23例EBER1阳性;EBVaGC组C-erbB-2蛋白表达显著高于EBVnGC组(P<0.05)。结论EBV感染可能上调了癌基因c-erbB-2表达。
The correlation of EBV infection and the expression of the c-erbB-2 gene in patients with gastric carcinoma was investigated, in which the EBV-encoded small RNA （EBER1） was detected from the paraffine section specimens of patients with gastric carcinoma by means of in situ hybridization, and the expressions of the C-erbB-2 protein was analyzed in EBV-positive and negative cases of patients by immunohistochemical assays. From the 217 cases selected, 23 cases were found to be EBERl-positive in the tissue specimens of gastric cancer patients, and the expression of C-erbB-2 protein was significantly higher in the EBV-positive cases than that in the EBV-negative cases. It is evident that EBV infection can up-regulate the expression of the oncogene c-erbB-2 in patients with gastric carcinoma.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2006年第7期606-608,共3页
Chinese Journal of Zoonoses
基金
教育部留学回国人员科研启动基金(教外司留〔2000〕479)
关键词
EB病毒
胃癌
癌基因
EBV
gastric carcinoma
oncogene
