摘要
目的：观察养血清脑颗粒(YQG)对慢性脑缺血大鼠脑血流量及认知功能的影响。方法：Wistar大鼠双侧颈总动脉永久结扎造成慢性脑缺血模型,激光多普勒血流仪检测额叶皮质局部脑血流量；Morris水迷宫检测认知功能。结果：术后模型组大鼠脑血流量骤降,并呈慢性持续下降趋势(P＜0．05)；大鼠出现认知功能障碍,隐匿平台逃避潜伏期和游泳距离明显延长(P＜0．05,P＜0．01),空间探索实验逃避潜伏期明显延长,穿越次数明显减少(P＜0．01),平台象限游泳时间和距离均缩短(P＜0．01)。YQG 3个剂量组均能明显增加脑血流量,改善认知障碍(P＜0．05或P＜0．01)。结论：YQG能明显改善慢性脑缺血大鼠局部脑血流量,提高学习记忆能力,有随疗程的增加而作用增强的趋势。
AIM： To investigate the effects of Yangxue Qingnao granules （YQG） on regional cerebral blood flow and cognitive functions in chronic cerebral ischemic rats. METHODS： Wistar rats were subjected to permanent bilateral common carotid arteries ligation in forming chronic cerebral ischemic models. Regional cerebral blood flow in the frontal lobe cortex was measured by laser-Doppler flowmetry in different stages. The learning and memory abilities were assessed with the Morris water maze. RESULTS： After the arterial ligation,the regional cerebral blood flow in the model group decreased sharply, and the reduction was progressively carried on （P 〈 0.05）, as well as the cognitive impairment. The escape latency and distance of swimming were significantly longer than those in sham-operated group （P 〈 0.05 ,P 〈 0.01 ）;the times of passing through the platform decreased significantly（P 〈 0.01 ）;and the time and distance of swimming in platform quadrant also decreased significantly （P 〈 0.01 ）. After treatment with YQG, the regional cerebral blood flow increased and the learning and memory abilities were improved （P 〈 0.05 or P 〈 0.01 ）. CONCLUSION： YQG has great promotive effect on the regional cerebral blood flow and cognitive functions in chronic cerebral ischemic rats. YQG in doses of 24, 12 g·kg^-1 show improving therapeutic effect progressively dependent on the course of treatment.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2006年第7期497-500,共4页
Chinese Journal of New Drugs and Clinical Remedies
基金
国家"十五"科技攻关项目(2001BA701A07-03)
关键词
脑缺血
局部血流
迷宫学习
记忆
养血清脑颗粒
cerebral ischemia
regional blood flow
maze learning
memory
Yangxue Qingnao granules
