摘要
目的：探讨西酞普兰合并尼莫地平治疗血管性抑郁的疗效和安全性。方法：135例血管性抑郁病人随机分为西酞普兰合并尼莫地平组68例[男性35例,女性33例；年龄(68±s4)a]：用西酞普兰20 mg,po,qd,尼莫地平30 mg,po,tid,西酞普兰组67例[男性38例,女性29例；年龄(68±5)a]：用西酞普兰20 mg,po,qd,疗程均为8 wk。根据汉密尔顿抑郁量表(HAMD)、临床疗效总评量表(CGI)、神经功能缺损评分(NDS)和简易精神状态量表(MMSE)评定疗效。结果：治疗8 wk后,西酞普兰合并尼莫地平组的有效率为84%,西酞普兰组有效率为42%,2组间比较有非常显著差异(P＜0．01)。2组间HAMD,CGI,NDS和MMSE总分比较有非常显著差异(P＜0．01)。西酞普兰合并尼莫地平组不良反应的发生率为48%,西酞普兰组为37%,2组间无显著差异(P＞0．05)。结论：西酞普兰合并尼莫地平治疗血管性抑郁症的疗效优于单用西酞普兰,安全性好。
AIM： To explore the effects and safety of nimodipine combined with citalopram in the treatment of vascular depression. METHODS ： One hundred and thirty five patients with vascular depression were randomly divided into 2 groups. Citalopram in combination with nimodipine group（n = 68, M 35, F 33;age（68 ＋ s 4） a） received citalopram 20 mg, po, qd, and nimodipine 30 mg, po, tid, for 8 wk. Citalopram group（n = 67, M 38, F 29; age（68 ＋ 5） a） received citalopram 20 mg, po, qd, for 8 wk. The effects were evaluated according to Hamilton rating scale for depression （HAMD）, clinical global impression （CGI）, neurologic deficit score （NDS）, and mini- mental state examination （MMSE ）. RESULTS： The effective rate of citalopram in combination with nimodipine group was 84 %, higher than that of citalopram group （42 %） （P 〈 0.01）. There were significant differences on the scores of HAMD, CGI, NDS, and MMSE between the 2 groups （P 〈 0.01）. In addition,the ratios of adverse reactions were revealed as 48 % and 37 % in combination group and citalopram group respectively, showing no statistically significant difference （P 〉 0.05）. CONCLUSION： Nimodipine combined with citalopram is more superior than citalopram alone in the treatment of vascular depression.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2006年第7期504-507,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
西酞普兰
药物疗法
联合
尼莫地平
抑郁
血管烂
citalopram
drug therapy, combination
nimodipine
depression, vascular
