摘要
目的检测系统性红斑狼疮(SLE)患者外周血转化生长因子β1(TGFβ1)的表达水平,初步探索TGFβ1在SLE发病中的作用及意义。方法采用双抗体夹心酶联免疫吸附试验(ELISA)检测52例SLE患者和20例健康人血清TGFβ1水平,并结合临床资料进行分析。结果活动组SLE患者血清TGFβ1表达明显低于正常对照组(685.8±397.3pg/m l vs 1354.3±174.0 pg/m l,P<0.01),亦低于稳定组患者(685.8±397.3pg/m l vs 1454.0±180.9 pg/m l,P<0.01);而稳定组患者和正常对照组之间无差别(P>0.05);SLE患者血清TGFβ1表达量与其疾病活动度SLEDAI积分成负相关(r=-0.64,P=0.002),与血小板数量和血红蛋白量成正相关(r分别为0.67和0.45,P分别为0.001和0.047),与其它实验室指标如24h尿蛋白定量、抗ds-DNA量等无明显相关性。结论活动性SLE患者血清TGFβ1的表达减少,提示TGFβ1在SLE的发病中起一定作用,并对判断病情活动度可能有一定临床意义。
Objective To investigate the serum level of transforming growth factorβ1 （TGFβ1） and its clinical significance in Systemic Lupus Erythematosus（SLE）. Methods Serum TGFβ1 from 52 SLE patients and 20 normal controls was measured using ELISA and analyzed accordingly. Results Serum TGFβ1 in the active SLE patients（685.8 ± 397.3 pg/ml） was lower than that in the normal controls （ 1354.3 ± 174.0 pg/ ml P 〈0. 01 ） , or that in the inactive SLE patients（ 1454.0 ± 180.9 pg/ml, P 〈0. 01 ） ; However there was no difference between the inactive SLE patients and normal controls （ P 〉 0.05 ） ; Serum TGFβ1 level in SLE correlated with PLT numbers（ r = 0.67, P = 0. 001 ） and Hb （ r = 0. 45, P = 0.047 ） while inversely correlated with SLEDAI （ r = - 0.64, P = 0. 002）. Conclusion： TGFβ1 may play certain role in the pathogenesis of SLE and may be a useful factor judging SLE activity.
出处
《临床和实验医学杂志》
2006年第7期906-907,共2页
Journal of Clinical and Experimental Medicine
