摘要
用自由基聚合合成了具有两亲性的N-异丙基丙烯酰胺(NIPAm)与衣康酸(IA)共聚物水凝胶(NIPAm-co-IA),利用互穿网络(IPN)技术合成了壳聚糖(CS)异丙基丙烯酰胺与衣康酸互穿网络水凝胶IPN(CS/NIPAm-co-IA)。研究表明,IPN(CS/NIPAm-co-IA)水凝胶具有良好的pH及温度敏感性,研究了其对辅酶A的控制释放,发现其对辅酶A具有良好的控制释放作用。
Hydrogel poly（NIPAm-co-IA） was synthesized by using N-isopropylacrylamide（NIPAm） and itaconic acid（IA）by radical copolymerization. IPN（CS/NIPAm-co-IA） was prepared by CS and hydrogel poly（NI- PAm-co-IA）by interpenetrating network process. The responses to temperature and pH were studied. The copolymer was also subjected tO coenzyme A adsorption study in order to assess its use in biomedical applications. The result was that IPN （CS/NIPAm-co-IA） could control the release of coenzyme A well.
出处
《化学与生物工程》
CAS
2006年第7期20-22,共3页
Chemistry & Bioengineering
关键词
pH及温度敏感性
互穿网络水凝胶
控制释放
pH and temperature responsive
IPN（CS/.NIPAm-co-IA）
controlled release
