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口服磺脲类、二甲双胍联合胰岛素治疗控制不良的2型糖尿病患者加用罗格列酮的疗效观察 被引量：2

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摘要 目的:探讨口服磺脲类、二甲双胍联合胰岛素治疗控制不良的2型糖尿病应用罗格列酮的疗效。方法:将52例磺脲类、二甲双胍联合胰岛素治疗控制不良的2型糖尿病患者随机分为罗格列酮组和对照组。治疗12周后,观察两组的血糖控制、胰岛素用量、血脂、体重的变化。结果:治疗12周后,与对照组相比,罗格列酮组血糖控制良好,明显优于对照组(P<0.01),且胰岛素剂量减少21.7%,而对照组胰岛素剂量却增加了19.1%。罗格列酮组甘油三酯较前有明显下降(P<0.01),胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、体重与治疗前无明显变化(P>0.05)。结论:对于口服磺脲类、二甲双胍药联合胰岛素控制不良的2型糖尿病患者,加用罗格列酮能使血糖得到较好的控制,是一种有效安全的选择。
作者 王毅飞 徐谷根 林延德 陈广原
机构地区 广州医学院第一附属医院内分泌科 广州军区广州总医院内分泌科
出处 《实用医学杂志》 CAS 2006年第15期1808-1810,共3页 The Journal of Practical Medicine
关键词 糖尿病 2型 二甲双胍 磺酰尿化合物 胰岛素 罗格列酮
分类号 R587.1 [医药卫生—内分泌] R977.15 [医药卫生—药品]
  • 相关文献

参考文献8

  • 1United Kingdom Prospective Diabetes Study 24:a 6-year,randomized,controlled trail comparing sulfonylurea,insulin and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy[J].Ann Intern Med,1998,128(3):165-175.
  • 2王毅飞,伊娜,张松,林延德.磺脲类合并二甲双胍失效的2型糖尿病患者应用胰岛素治疗和联合治疗方案的临床观察[J].实用医学杂志,2003,19(7):736-737. 被引量：2
  • 3王毅飞,伊娜,张松,徐谷根,林延德.胰岛素加用罗列酮治疗血糖控制不良的2型糖尿病患者疗效观察[J].中国实用内科杂志,2004,24(7):434-435. 被引量：5
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二级参考文献11

  • 1UKPDS Group. A 6-year randomized prospective controlled trail comparing sulfonylurea, insulin and metformin therapy in patients with newly diagnesed type 2 diabetes that could not be controlled with diet therapy.Ann Intern Med, 1998,128(2) : 165 ~ 175.
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  • 7UKPDS Group. A 6-year randomized prospective controlled trial comparing sulfonylurea, insulin and mefformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy. Ann Intern Med,1998,128(3) :165-175
  • 8Buse JB, Gumbiner B, Mathias NP, et al. Troglitazone use in insulintreated type 2 diabetes patients. Disbet Care, 1998,21(9): 1455-1461
  • 9Paskin P, Rendell M, Riddle MC, et al. A randomized trial of rosiglitazone therapy in patients with inadequately controlled insulin-treated type 2 diabetes. Diabet Care,2001,24(7):1226-1232
  • 10Buch HN, Baskar V, Barton DM, et al. Combination of insulin and thiazolidinedione therapy in massively obese patients with type 2 diabetes. Diabet Med,2002,19(7):572-574

共引文献5

同被引文献15

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二级引证文献20

实用医学杂志
2006年 第15期

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