摘要
目的观察重组人白细胞介素-11（rhIL-11）治疗急性白血病（AL）化疗后血小板减少的疗效.方法AL患者52例,其中27例在化疗结束后血小板计数（BPC）＜30×109/L时开始用rhIL-11治疗.ELISA法检测化疗前及BPC＜30×109/L后7、14 d促血小板生成素（Tpo）水平,流式细胞分析法测定网织血小板百分率（RP%）及其绝对值（RPC）.25例未用rhIL-11治疗者为非用药组,从化疗后BPC＜30×109/L开始观察14 d.30名正常人作为对照.结果①rhIL-11用药组第7、14天血小板计数较非用药组明显增高;用药患者组23例需要输注血小板,平均为4～10 U;对照组27例,平均为10～15 U.②急性白血病患者化疗前Tpo水平较对照降低,RP%与对照组比较差异无统计学意义,但RPC较对照组明显降低.③非用药组第7天患者血浆Tpo水平,RP%及RPC均较对照及化疗前明显降低,第14天Tpo水平,RP%、RPC有所升高但仍较对照低.④用药组第7天血浆Tpo水平,RP%及RPC均较非用药组高;Tpo水平,RP%与对照组比较差异无统计学意义而RPC较对照低,第14天均高于对照.结论rhIL-11治疗AL化疗后血小板减少有效;IL-11可能有利于骨髓基质的恢复,具有促进Tpo合成或释放作用,使巨核细胞的血小板生成能力增强从而血小板生成增多.
Objective To investigate the efficacy and possible mechanism of rhlL-11 in the management ot chemotherapy-induced thrombocytopenia in acute leukemia. Methods Twenty-seven acute leukemia patients were inrolled in study, rhIL-11 was given when platelet count dropped below 30×10^9/L after chemotherapy.Serum Tpo levels before and 7 days ,14 days after platelet count was below 30×10^9/L were determined by ELISA.The percentage of reticulated platelets（RP%） and reticulated platelets count （RPC）were measured by flow cytometry. The other 25 patients without treatment of rhIL-11 were non-treatment group and 30 normal people were the control group. Result ①The platelet counts on day 7 and 14 after medication for 27 patients in IL-11 group were higher than that for the non-treatment group （P〈0.05）.There were 23 patients who received fewer platelet transfusion in rhIL-11 group than that in non-treatment group.②Serum Tpo level of acute leukemia patients was lower than normal group（P〈0.05）before chemotherapy,RP% had no statistic difference with normal group while RPC was lower than the normals. ③Serum Tpo,RP% and RPC of non-treatment group on day 7 after chemotherapy were all apparently lower than normal and pre-chemotherapy（P〈0.05）. On day 14,Tpo and RP% increased but still was lower than normal（P〈0.05）.④Tpo,RP% and RPC on day 7 of rhIL-11 group were all higher than non-treatment group（P〈0.05）.Tpo and RP% had no statistic difference with normal group while RPC was lower than the normal.On day 14, Tpo,RP% and RPC were all higher than normal（P〈0.05）.Conclusion rhIL-11 is effective for the theatment of chemotherapy-induced thrombocytopenia in acute leukemia, rhIL-11 can accelerate the recovery of marrow matrix and promote the synthesis and releasement of Tpo so as to increase platelet count and decrease platelet transfusion.
出处
《中国药物与临床》
CAS
2006年第7期496-498,共3页
Chinese Remedies & Clinics
基金
山西省归国留学人员基金资助项目(2005069)
