摘要
【目的】探讨慢性心力衰竭(CHF)患者血清白介素6(IL-6)和白介素8(IL-8)水平的变化。【方法】采用双抗体夹心ELISA法检测56例CHF患者及25例健康人血清IL-6和IL-8水平。【结果】①CHF患者IL-6和IL-8水平显著高于健康人(P<0.01);②血清IL-6和IL-8水平与CHF患者左室射血分数(LVEF)呈负相关(r分别为-0.62和-0.49,P均<0.01),与CHF的原发病无关。【结论】IL-6和IL-8参与了CHF的病理生理过程,并与CHF病情严重程度密切相关。
[Objective]To investigate the levels of interleukin-6 （IL-6） and interleukin-8 （IL-8） in patients with congestive heart failure（CHF）. [Methods]The levels of IL-6 and IL-8 in 56 patients with CHF and 25 normal controls were studied by enzyme-linked immunosorbent assay, [Results]①IL-6 and IL-8 levels were higher in CHF group compared with those of control group;② IL-6 and IL-8 levels were negatively related to left ventricular ejection fraction（r=0.62 and -0.49, respectively;P〈0.01 ）, but not related to the primary diseases of CHF. [Conclusion]Elevated IL-6 and IL-8 levels are present in patients with CHF, and they may play an important role in pathophysiologic changes of CHF.
出处
《医学临床研究》
CAS
2006年第7期1041-1042,共2页
Journal of Clinical Research
