摘要
目的探讨诺和锐30强化治疗对初诊2型糖尿病患者血糖及胰岛功能的影响。方法对40例初诊2型糖尿病患者进行2周的诺和锐30治疗,分析治疗前后空腹血糖(FPG)及餐后2h血糖(2hPG)、糖化血红蛋白(HbA lc)、静脉葡萄糖耐量试验第一时项胰岛素及C肽分泌和胰岛素及C肽曲线下面积、胰岛素抵抗指数、胰岛素分泌指数、胰岛素敏感指数、空腹胰岛素(FINS)与FPG比值。结果诺和锐30治疗后,FPG、2hPG、HbA lc、胰岛素抵抗指数均较治疗前明显下降(P<0.01);空腹及第一时项胰岛素和C肽的分泌、胰岛素及C肽曲线下面积、FINS与FPG比值、胰岛素分泌指数、胰岛素敏感指数均较治疗前明显升高(P<0.01)。结论诺和锐30强化治疗能显著改善初诊2型糖尿病患者的血糖及胰岛功能。
Objective To explorc the effect of insulin aspart 30 intensive treatment on plasma glucose and pancreatic function in newly diagnosed type 2 diabets. Methods Forty patients with newly diagnosed type 2 diabetes were treated by 2 weeks insulin aspart 30 treatment. The level of fasting plasma glucose （FPG） ,2 hours postprandial glucose（ 2hPG）, glycosylatcd hemoglobin Alc （HbAlc） , the first- phase secretior of insulh and C-peptide, the mean area under the curve（AUC） of insulin and C -peptide,insulin resistance index（ HOMA- A ）, insulin secretion index（ HOMA- B）, insulin sensitivity index（ 1SI ） and the ratio of fasting insulin to fasting glucose （ FINS/FPG ） were compared before and after insulin aspart 30 treatment. Results After the treatment, FPG（ 18 vs 6. 5mmol/L） ,2hPG（26 vs 9mmoL/L） ,HbAlc（ 12% vs 10% ）and HOMA - A（0. 35 vs 0. 26） were signifi- cantly decreased（ all P 〈 0. 01 ） ; fasting and the first - phase secretion of insulin and C - peptide, AUC of insulin （ AUCins ）, FINS/FPG, HOMA - B and ISI greatly increased （all P 〈 0.01 ）. Conclusion Insulin aspart 30 intensive treatment can effectively improve plasma glucose and pancreatic function in newly diagnosed type 2 diabetes.
出处
《临床医学》
CAS
2006年第7期9-11,共3页
Clinical Medicine
关键词
诺和锐30
2型糖尿病
血糖
咦岛功能
Insulin aspart 30
Type 2 diabetes mellitus
Plasma glucose
Pancreatic function
