摘要
目的：观察爱维治（小牛血去蛋白提取物）防治急性放射性黏膜损伤的疗效。方法：35例头颈部肿瘤术后患者，随机分成2组：治疗组（17例），对照组（18例）。治疗组予常规口腔护理，同时全疗程静滴爱维治；对照组予常规口腔护理，出现黏膜损伤后静滴维生素。根据RGOT急性放射性黏膜损伤分级标准及疼痛的VAS评分进行临床评价，观察急性口咽黏膜损伤出现时间、程度及药物不良反应。结果：2组患者均发生程度不等的急性放射性黏膜损伤；2组间黏膜损伤出现的时间比较差异有显著性（P：0．0002）；治疗组以Ⅰ、Ⅱ级口咽黏膜损伤为主（76．5％），对照组以Ⅲ、Ⅳ级的损伤为主（61．1％），2组间比较差异均有显著性（P=0．0409）；治疗组以轻度疼痛为主（VAS评分0～3分，70．6％），对照组以中度疼痛为主（VAS评分4～6分，61．1％），2组间比较差异均有显著性（P：0．0067）；对照组放疗中断的病例较多，但2组比较无显著性（P=0．3377）；未见药物不良反应。结论：爱维治可推迟放射性黏膜损伤的发生，并降低Ⅲ、Ⅳ级黏膜损伤的发生率。
Objective ：To evaluate the effect of actovegin in the prevention of acute mucositis induced by radiotherapy. Methods：35 postoperative patients with head and neck cancer were randomized into treatment group （17 cases ） and control group （ 18 cases ）. Patients in the treatment group received concurrently intravenous infusion of actovegin and regular oral cavity nursing during irradiation course. Patients in the control group received daily regular oral cavity nursing and intravenous infusion of vitamins when mucous membrane injury was found. Acute irradiation oropharyngeal mucositis was evaluated according to the protocol proposed by RTOG. The pain degree was estimated using VAS. Results：Comparing with the rate of acute irradiation mucositis between the two groups, there was no significant difference （ P 〉 0.05 ）. Regarding to the grade of irradiation mucositis, the majority of patients in the treatment group were at stage Ⅰ -Ⅱ ,while those in the control at stage Ⅲ - Ⅳ（P 〈0.05）. Mucous membrane injury was found （ 18.2 ± 6.0） d after the begining of irridation in treatment group and （ 10.6 ± 4.7 ） d in control group（ P 〈0.01 ）. Patients in the treatment group were mostly in low-grade pain felling（ VAS 0 -3, 70.6% ）and those in the control were mostly in midding-grade（ VAS 4 - 6,61.1% ） （ P 〈0.01 ）. Therapy interruption rates were not significantly different between the two groups （P 〉 0.05 ）. No adverse drug reaction was observed in both groups during irradiation process. Conclusion： Actovegin can postpone the development of irradiation oropharyngeal mucositis and decrease the incidence of grade Ⅲ and Ⅳ mucositis.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2006年第4期496-498,共3页
Journal of Practical Stomatology
