摘要
目的:探讨Ecadherin、粘着斑激酶在肝细胞癌中的表达及其临床病理意义。方法:应用免疫组化SP法检测42例肝细胞癌、13例正常肝细胞中Ecadherin、粘着斑激酶的表达。结果:1)Ecadherin在正常肝细胞、癌旁组织及肝癌组织中的阳性表达率分别为76.92%(10/13)、25.00%(24/32)、23.80%(10/42)。肝癌组织与前二组阳性表达率比较差异有统计学意义(P=0.010,P=0.000)。2)粘着斑激酶在正常肝细胞及癌旁组织中多数呈阴性表达,在肝癌细胞粘着斑激酶阳性表达率为71.42%(30/42),与前两组比较差异有统计学意义(P=0.000,P=0.001)。3)高侵袭转移组与低侵袭转移组间,Ecadherin阳性率分别为27.27%(6/22)和60.00%(12/20),组间差异有统计学意义,(P=0.033);粘着斑激酶阳性率分别为59.09%(13/22)和25.00%(5/20),组间差异有统计学意义(P=0.020)。结论:Ecadherin在肝癌细胞表达缺失、粘着斑激酶在肝癌细胞高表达与肝细胞癌的发生、侵袭和转移有关。
OBJECTIVE： To study the significance of expres sions of E-cadherin and FAK in hepatocelltdar carcinoma （HCC）. METHODS： The expressions of E-cadherin and FAK were deter mined by staining （SP methods ） in the sam pies of HCC and normal hepatic tissues. RESULTS： 1）There was a significant difference about the positive rate of E-cadherin of HCC and the tissue near HCC or normal hepatic tissue respectively （P=0.010,P=0.000）. 2）The expression of FAK in numerous tissue of near HCC and normal hepatic was negative, and the positive rate of FAK in HCC was 71.42%（30/42）, and there was a significant difference（P=0.000,P=0. 001）. 3）In higher invasive and metastatic group, the positive rate of E-cadherin was 27.27 %（6/22）, and in the lower invasive and metastatic group it was 60.00%（12/20）, and there was a significant difference statistically, P=0. 033. The positive rates of FAK in the two above mentioned groups were 59.09%（13/22） and 25.00%（5/20）respectivdy, and there was a significant difference （P=0. 020）. CONCLUSION： The activity of tumor cell including occurrence, invasion and metastasis is correlated with the reduced membranous expression of E-cadherin and the over expression of FAK in HCC.
出处
《中华肿瘤防治杂志》
CAS
2006年第12期926-928,共3页
Chinese Journal of Cancer Prevention and Treatment
