摘要
为观察氟西汀在癌症疼痛的治疗中对三阶梯止痛治疗的增强作用以及对患者抑郁、焦虑状态的影响。对70例伴有疼痛肿瘤患者随机分为治疗组和对照组,每组35例。对照组采用WHO三阶梯给药原则与方法,治疗组在此基础上加用氟西汀。用药6周后比较2组在疼痛缓解率和抑郁、焦虑状态方面的差异。结果显示,治疗组与对照组疼痛缓解率分别为83.30%和55.6%,两组比较有显著性差异(P<0.05);治疗组患者治疗后其焦虑自测量表(SAS)与抑郁自测量表(SDS)评分明显降低。初步研究结果提示,氟西汀可增强镇痛效果,缓解患者的焦虑、抑郁状态,且不良反应少。
70 patients with different cancer types were randomized into two groups. To compare the effect of pain relief and status of depression and anxiety of three step ladder analgesia with or without Florentine. Group A： Three step ladder analgesia with Florentine, and Group B： Three step ladder analgesia alone. The pain relief rate, QoL and status of depression and anxiety were compared between the two groups 6 weeks after the treatment. Pain relief rate in Group A and Group B were 83.3 % and 55.6 % respectively. The difference was statistically significant （P〈0.05）. The scores of self rating depression scales （SDS） and self rating anxiety scales （SAS） decreased significantly in Group A. Fewer side effects were observed in Group A than that in Group B. In conclusion adding Florentine to Three step ladder analgesia can enhance the effect of analgesia for patients with advanced cancer and with fewer side effects. It can also improve the QoL and relieve the depression and anxiety of patients with advanced cancer.
出处
《中华肿瘤防治杂志》
CAS
2006年第12期947-948,共2页
Chinese Journal of Cancer Prevention and Treatment
关键词
氟西汀
癌症
疼痛
三阶梯止痛
抑郁
焦虑
fluoxetine
cancer
pain
quality of life
depression
Anxiety
