摘要
以５－氟尿嘧啶（５－ＦＵ）为药物模型，以乳酸－磷酸酯共聚物为高分子药物载体，合成了侧链带药的乳酸－磷酸酯共聚物药物。用１ＨＮＭＲ、ＩＲ、ＵＶ谱对其结构进行了表征。测定高分子药物中５－ＦＵ的含量，研究了高分子药物的体外释药性能及共聚物组成对释药性能的影响。
A kind of polymer drug,using 5-flurouril as model drug,lactic acid-phosphate copolymers as polymer drug carriers,was synthesized.The copolymers were characterized by 1H NMR,IR and UV spectroscopy.The contents of 5-fluorouril were determined by UV spectroscopy.The drug release in vitro of the copolymers was studied and the influence of the copolymer composition on the drug release in vitro was investigated.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1996年第11期1788-1791,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
