摘要
不少药物因临床发现有抑制hERG钾离子通道导致心律失常而被撤出市场,本文从hERG钾通道的生物学基础,阻断hERG钾离子通道的高危险性及采用计算机虚拟预测药物对hERG钾离子通道阻滞活性的研究方法分别进行了介绍和综述,并分别从基于受体和基于配体两个角度对各种预测药物阻滞hERG钾离子通道活性的方法的研究进行阐述和比较。
Many drugs were withdrawn from the market due to its serious side-effects such as cardiotoxicity after blocking hERG potassium channel. The biological characteristics of hERG potassium channel, high risks resulting from blocking this channel and in silico prediction of the interaction between drugs and hERG potassium channel are presented in this review. Efforts are made to characterize andaccount for the different characteristics and objectives of various in silico approaches, including receptor-based, and ligand-based approaches.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2006年第4期291-296,共6页
Journal of China Pharmaceutical University
