摘要
采用微波辐射﹑离子液体和无溶剂无催化剂三种绿色合成方法,分别进行了以亚磷酸酯、邻氟苯甲醛和对三氟甲基苯胺为原料的类Mannich一锅法合成反应研究,经合成筛选,优选出控制反应温度100℃、无溶剂和无催化剂加热反应15min的合成方法,实验结果表明该方法经济、简便、产率高、反应时间短及对环境友好.
The Mannich-type addition of O,O＇-dialky phosphite to 2-fluorobenzaldehyde and 4-trifluoromethylaniline was carded out in one pot by means of adopting three kinds of green synthetic methods, microwave irradiation, ionic liquid and free solvent-catalyst condition. According to the results, the synthetic method was optimized without catalyst and solvent at 100℃ and 15 min, and it was economic, convenient, high yields, timesaving and environment friendly.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2006年第8期1136-1139,共4页
Chinese Journal of Organic Chemistry
基金
国家973计划(No.2003CB114404)
国家自然科学基金(No.20362004)
教育部博士点基金(No.20040657003)资助项目.
