摘要
目的:探讨碱性成纤维细胞生长因子(bFGF)、微血管密度(MVD)与肝细胞癌(HCC)的关系,为临床诊断、判断病程及预后、寻找新的治疗方法提供理论依据。方法:使用免疫组化法检测41例肝细胞癌手术切除标本(其中包膜完整者12例,不完整者29例;无癌栓者13例,有癌栓者28例;病理分级Ⅰ+Ⅱ级者17例,Ⅲ+Ⅳ级者24例)和5例正常肝组织中bFGF和MVD的表达。结果:5例正常肝组织中bFGF和MVD均无表达。HCC组织中bFGF阳性率为70.7%,bFGF表达与肝癌分化程度、有无癌栓、包膜是否完整有关(P<0.05),HCC组织中MVD为21.02±9.57。bFGF表达与MVD值有关(P<0.01)。在高侵袭转移组与低侵袭转移组间,bFGF阳性率分别为86.4%和52.6%,差异有统计学意义(P<0.05);2组MVD值分别为24.62±9.98,16.79±9.22,差异有统计学意义(P<0.01)。结论:HCC组织中bFGF呈高表达,与HCC肿瘤血管生成有关,检测bFGF、MVD有助于判断肿瘤侵袭转移能力。
Aim： To study the significance of detecting bFGF and MVD in hepatocellur carcinoma （HCC） tissue. Methods：The expression of bFGF and MVD were detected using immunohistochemistry method in 41 samples of HCC and 5 cases of normal liver tissue. Results ： Neither bFGF nor MVD was detected in 5 cases of normal liver tissue. The positive rate of bFGF in HCC tissue was 70.7% （29/41）. There were significant differences between well and poor differentiation groups, well and poor defined capsule, with and without portal embolus （P 〈0.05）. MVD in HCC tissue was 21.02 ± 9.57. The expression of bFGF was related to MVD （P 〈0.01 ）. In high invasive group, the positive rate of bFGF was 86.4% , which was 52.6% in low invasive group, and there was significant difference （ P 〈0.05 ）. The value of MVD in the two groups was 24.62 ± 9.98 and 16.79 ± 9.22, respectively, and there was significant difference （P 〈0. 01 ）. Conclusion： bFGF is overexpressed in HCC tissue, which is associated with angiogenesis of HCC. bFGF and MVD can be used as markers judging the metastasis ability of HCC.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2006年第4期704-706,共3页
Journal of Zhengzhou University(Medical Sciences)
