摘要
目的:研究阿托伐他汀对急性心肌梗死(AMI)患者早期血浆中血脂、一氧化氮(NO)、降钙素基因相关肽(CGRP)和内皮素(ET)的影响。方法:48例AMI患者随机分为2组,常规用药组(即常规组,应用溶栓剂、抗凝剂、β受体阻滞剂、钙通道阻滞剂、硝酸盐、ACEI类等)24例,常规用药加用阿托伐他汀组(即联用组)24例,并设正常对照组24例。用Greiss法测定NO,应用放射免疫法测定治疗前后血中CGRP和ET的水平。并测定治疗前后的血脂(TC,TG,LDLC,HDLC)水平。结果:AMI患者早期血浆中NO和CGRP水平明显低于正常对照组(P<0.01),ET显著高于正常对照组(P<0.01),治疗后AMI患者上述指标均显著改善(P<0.01),且以联用组改善更为显著;联用组治疗后与治疗前比较TC,TG,LDLC明显降低,HDLC明显升高。结论:常规用药加用阿托伐他汀能显著降低AMI患者的血脂水平,改善AMI患者早期血浆中NO、CGRP和ET的代谢失衡,改善血管内皮功能。
Aim ： To study the influence of atorvastatin on plasma nitric oxide（NO） , calcitonin gene-related peptide （CGRP） and endothelin （ET） in patients with early stage of acute myocardial infarction （AM I） . Methods： A total of 48 patients with AMI were divided into two groups： rountine treatment group, rountine treatment plus atorvastatin group, and 24 normal controls were chosen as normal control; the plasma NO,CGRP, ET and TC ,TG,LDL-C, H DL-C levels were observed before and after treatment. Results： The levels of NO, CGRP in patients with AMI were lower than those in normal control group （ P 〈 0.01 ） , and the level of ET was higher （ P 〈 0.01 ） , which were improved after treatment （ P 〈 0.01 ）. The improvement of NO, CGRP and ET in atorvastatin group was better than that in the rountine treatment group （P 〈 0.05）. Conclusion： Vascular endothelial function deterioration is observed in patients with AMI. Atorvastatin can improve vascular endothelial function in patients with AMI.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2006年第4期725-728,共4页
Journal of Zhengzhou University(Medical Sciences)
关键词
阿托伐他汀
急性心肌梗死
血管内皮功能
一氧化氮
降钙素基因相关肽
内皮素
atorvastatin
acute myocardial infarction
vascular endothelial function
nitric oxide
calcitonin gene-related peptide
endothelin
