摘要
目的:研究云南狗牙花总碱(total Ervatamia yuunansis alkaloid,TEYA)对小鼠的镇痛作用。方法:采用小鼠热板法,观察TEYA的镇痛作用及对吗啡的镇痛作用的影响。结果:与同期对照组相比,TEYA的3个剂量组均可显著提高小鼠的病阈值,镇痛效果随剂量的增加呈剂量依赖关系;同时给予TEYA(10、20mg/kg)和吗啡4mg/kg,有协同镇痛的作用;纳洛酮4mg/kg可以部分拮抗TEYA的镇痛作用。结论:TEYA有明显的镇痛作用,其作用可能部分通过阿片受体来实现。
Objective: To observe the antinociceptive effect of total Ervatamia yunnansis alkaloid(TEYA) in mice. Methods: The mice hot-plate antinociceptve test was used to study the analgesic effects of TEYA and the effect on morphine in mice. Results: The three groups with different dosage of TEYA could significantly increase the pain threshold in mice and the effects increased in a dose-related manner. TEYA( 10,20 mg/kg) combined with morphine 4 mg/kg had a synergic analgesic eftect. The analgesic effect of TEYA could be partly blocked by naloxone 4 mg/kg. There were significantly differences between administration group and control group in the hot-plate test. Conclusion: TEYA has significant antinocieeptive activity in hot-plate test in mice which may be mediated by way of opioid receptors.
出处
《药学实践杂志》
CAS
2006年第4期203-205,共3页
Journal of Pharmaceutical Practice
基金
国家自然科学基金资助项目(NO.20272081)
关键词
云南狗牙花总碱
镇痛作用
小鼠
total Ervatamia yunnansis alkaloid
analgesia
mice