摘要
AIM： Celiac disease is characterized by life-long gluten intolerance. Clinical features of patients with celiac disease are variable. Studies about the prevalence of celiac disease in our country are scarce and there is no study on the prevalence of celiac disease in southern Iran. In the current study, clinical, laboratory and histological features of 52 patients with celiac disease were evaluated. METHODS： In a cross sectional study we retrospectively studied the characteristics of 52 celiac patients at Ahwaz JundiShapour University Hospitals （AJSUH） from November 1, 1999 to 1st Sep 2004. Intestinal biopsy and serum antigliadin and anti-endomysium antibodies were used for the diagnosis of patients. Mucosal lesions were classified according to the criteria of Marsh. Antigliadin antibodies were measured with a commercial enzyme-linked immunosorbent assay. Anti-endomysium antibodies were analyzed by indirect immunofluorescence with the use of a section of monkey esophagus. Routine hematological and biochemical analyses and measurement of immunoglobulin levels were undertaken.RESULTS： Male： female ratio was 1.08. The mean ＋ SD patient age was 21 ＋ 4.5 years （range 10-70 years） and the most common symptoms were diarrhea and weight loss （78.8%） followed by fatigue （73.1%）, pallor （65.4%）, anorexia （40.4%）, abdominal distention （32.7%）, and failure to thrive （23.1%）. Diarrhea and weight loss and fatigue were the most common findings. Iron deficiency anemia was found in 63.2% of patients and this became normal after adoption of a gluten-free diet in all patients. Immunoglobulin A, IgG antigliadin antibodies and IgA anti-endomysium antibodies were found in 33 and 48 cases, 78.8% and 85.4% of patients, respectively. Biopsy of the small intestine revealed that 90.4% of patients had typical lesions according to the Marsh classification. CONCLUSION： Although classical presentation was seen in most of the patients, atypical clinical manifestations of celiac disease should be kept in mind. In particular, patients with uncommon findings, such as short stature, and iron-deficiency anemia, should be screened for celiac disease. Further epidemiological studies in our area in the general population and in high risk groups seem to be indicated.
瞄准：乳糜泻被终生的面筋不耐描绘。有乳糜泻的病人的临床的特征是可变的。关于在我们的国家的乳糜泻的流行的研究是少见的，在南部的伊朗的乳糜泻的流行上没有学习。在当前的学习，临床，实验室和有乳糜泻的 52 个病人的组织学的特征被评估。方法：在生气部分研究，我们回顾地从 1999 年 11 月 1 日在阿瓦十 JundiShapour 大学医院(AJSUH ) 学习了 52 个腹的病人的特征到 2004 年 9 月 1 日。肠的活体检视和浆液反麦胶蛋白质和 anti-endomysium 抗体被用于病人的诊断。粘膜损害根据沼泽地的标准被分类。Antigliadin 抗体与商业连接酶的免疫吸着剂试金被测量。Anti-endomysium 抗体被间接免疫荧光与猴子食管的节的使用分析。免疫球蛋白层次的平淡的 hematological 和生物化学的分析和测量被承担。结果：男性：女比率是 1.08。吝啬的+/- SD 耐心的年龄是 4.5 年(范围 10-70 年)和最普通的症状是的 21 +/-腹泻和重量损失(78.8%)由疲劳(73.1%)列在后面，苍白(65.4%)，厌食(40.4%)，腹部膨胀(32.7%)，并且繁荣的失败(23.1%)。腹泻和重量损失和疲劳是最普通的调查结果。铁营养缺乏性贫血在 63.2% 病人被发现，这在所有病人在一本没有面筋的食谱的采纳以后变得正常。免疫球蛋白 A， IgG 反麦胶蛋白质抗体和 IgA anti-endomysium 抗体在 33 和 48 个盒子中被发现， 78.8% 病人和 85.4% 分别地。小肠的活体检视表明 90.4% 病人根据沼泽地分类有典型损害。结论：尽管古典表示在大多数病人被看见，乳糜泻的不正常的临床的表明应该被记住。特别地，有不平常的调查结果的病人例如短身高，和铁缺乏贫血症，应该为乳糜泻被屏蔽。在我们在一般人口并且在高风险组的区域的进一步流行病学的研究似乎被显示。
