摘要
目的：通过１６只兔子垂体ＭＲＩ和组织切片的对照研究，了解ＭＲＩ上垂体后叶高信号产生或消失的组织病理学基础。材料与方法：实验组８只（１～８号）在２％氯化钠溶液喂养前、后１５天分别进行垂体矢状面Ｔ１加权ＭＲＩ（０．５Ｔ），观察后叶信号强度。其中４只（１～４号）第２次成像后处死做垂体组织切片，观察垂体后叶含抗利尿激素（ＡＤＨ）的神经分泌颗粒含量。另４只（５～８号）经水喂养１５天后再行ＭＲＩ检查，并处死作垂体组织切片。结果：实验组（１～８号）在２％氯化钠溶液喂养前Ｔ１加权ＭＲＩ垂体后叶均呈现高信号，喂养１５天，后叶高信号消失。组织切片示垂体后叶神经分泌颗粒含量稀少。４只（５～８号）经水喂养后第３次ＭＲＩ，垂体后叶高信号复现。组织切片示垂体后叶充满神经分泌颗粒。对照组８只（９～１６号），其中４只（９～１２号）行垂体ＭＲＩ检查后处死，见垂体后叶呈高信号且充满含ＡＤＨ神经分泌颗粒而无脂滴；另４只（１３～１６号）经水喂养１５天后与实验组（５～８号）同步进行ＭＲＩ，结果见后叶信号强度无改变。结论：本实验研究表明垂体后叶高信号主要来源于含ＡＤＨ的神经分泌颗粒。
Purpose:Toinvestigateonthehistochemicalbasisofhighsignalintensityofthepos-teriorlobe(PL)ofthepituitaryglandbyexperimentalstudy.Materialsandmethods:Theexperi-mentgroupconsistedof8rabbits(No.1～18)whichwereimagedwithsagittalT1-weightedMRI(0.5T)beforeandafter15daysoffeedingof2%NaCl,tostudythesignalofthePL.Four(No.1～4)werekiledsoonafterthesecondimaging,thepituitaryglandwasthenexaminedhistochemicalyforneurosecretorygranulescontainingADH.Theotherfour(No.5～8)weregivenwaterforanoth-er15days,thenimagedandkiled.Results:InNo.1～8,thePLwashyperintenseonT1-weightedMRIbeforefeedingof2%NaCl.After15dayfeedingof2%NaCl,thesignalintensityofthePLde-creased.Theneurosecretorygranulessignificantlydiminishedhistochemicaly.Hyperintensityreap-pearedatthethirdMRIafter15daywaterfeedinginNo.5～8rabbits.Theneurosecretorygranuleswerefoundtoreturntothenormalrange.Thecontrolgroupconsistedof8rabbits(No.9～16),fourrabbits(No.9～12)wereexaminedhistochemicalyafterMRI,thePLofpituitarycontainedalotofneurosecretorygranulescontainingADH,nolipiddropletswereobserved.Theotherfour(No.13～16)afterfeedingwaterfor15dayswerethenexmainedwithMRI,hyperintensityofthePLremainedunchanged.Conclusion:TheresultsstronglysuggestedthatthebasisofthePListheneurosecretorygranulescontainingADH,butnotlipiddroplets.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
1996年第10期689-691,共3页
Chinese Journal of Radiology
关键词
垂体后叶
垂体激素
NMR
成像
Pituitarygland,posteriorlobePituitaryhormoneMagneticresonanceimag-ing
