摘要
目的探讨Percusurge远端保护装置(DPD)在急性心肌梗死(AM I)PC I中对P-选择素(Ps)、纤溶酶原激活剂(t-PA)、纤溶酶原激活剂抑制物-1(PAI-1)的影响及作用机制。方法接受急诊PC I治疗的AM I患者72例,DPD组39例,对照组33例,经股静脉将6F右冠状动脉造影导管置入冠状静脉窦于PTCA前、DPD后即刻、0.5、2、6 h采血分别检测血中Ps,t-PA,PAI-1水平。结果①DPD组术后6 h Ps含量降低(P<0.05)与对照组比较在术后6 h有显著性差异(P<0.05);术后即刻至术后6 h血浆t-PA活性降低(P<0.05)与PAI-1含量升高(P<0.05),与对照组比较无统计学差异。②两组住院期间心血管病事件发生率无明显统计学差异。结论Percusurge远端保护装置能有效保护远端血管,减轻PTCA术后血小板的激活,减少再灌流后无复流的发生。
AIM To investigate influences of Percusurge distal protection device （DPD） on the level of P-selection, tissue-type plasminogen activator and plasminogen activator inhibitor-1 during coronary intervention with acute myocardial infarction. METHODS 72 acute ST-elevation myocardial infarctiion patients received primary coronary intervention were included into this study. Patients were divided into two groups, test group： percusurge DPD were attempted during emergency PCI （ n = 39 ） ; control group： percusurge DPD were not attempted（ n = 33 ）. Placing a right coronary artery catheter into the coronary sinus, blood samples were drawed to measure plasma P-selection （Ps）, tissue type plasminogen activator（ t-PA）, plasminogen activator inhibitor-1 （ PAI-1 ）. RESULTS ①The test group Ps level after 6 hours PCI was significantly lower than that of control group （ P 〈 0.05 ）. The t-PA level decreased and PAI-1 level increased significantly during the frist 6 hours after the PCI, but both of them were not significant different with control group （ P 〈 0.05 ） ; ②The incidence rate of major adverse cardiac events （ MACE ） was no significant difference between two groups during hospitalization. CONCLUSION DPD can protect the distal vessels, reduce the activity of the platelet, and the ies reperfusion in acute myocardial infarction. no-flow phenomenon in the thrombus laden arteries reperfusion in acute myocardial infarction.
出处
《心脏杂志》
CAS
2006年第4期432-435,共4页
Chinese Heart Journal
基金
西京医院科技创新基金项目资助(No.XJCX03M019)
