摘要
目的观察奈达铂（NDP）联合5-氟脲嘧啶（5-Fu）治疗晚期食管癌的临床疗效。方法38例晚期食管癌患者应用NDP80mg／m^2,静脉滴注，第1天；5-Fu500mg／m^2，静脉滴注，第1～5天，每3周重复，至少2个周期。结果入组的38例中36例可评价疗效，其中CR0例，PR15例，SD16例，PD5例，总有效率（RR）41．7％；中位缓解期5．2个月；中位生存期9个月，主要毒副反应为骨髓抑制。结论奈达铂联合5-Fu治疗晚期食管癌疗效较好，毒副反应较小，患者耐受性好，值得临床推广应用。
Objective To evaluate the efficacy and toxicity of Nedaplatin（NDP） combination With 5-Fluorouracil（5-Fu） treatment in the advanced esophageal cancer. Methods Thirty-elght patients of advanced esophageal cancer were treated. The treatment schedule was consist of NDP 80 mg/m^2 iv, di; 5-Fu 500 mg/m^2 iv, 1/d, d1 -5. Cycles repeated for 21days. Eevery patient received over 2 cycles of chemotherapy. Results 36 cases of 38 patients were eligible for clinical response evaluation. The overall response rate was 41.7 %,including O case of CR, 15 cases of PR, 16 cases of SD and 5 cases of PD respectively. The median response duration was 5.2 months. The median survival period was 9 months. The major side effect was bone marrow suppression. ConclnsionThe NDP and 5-Fu combination has a palliative role in patients with advanced esophageal cancer. Such regimen is valuable for clinical generalizing.
出处
《实用癌症杂志》
2006年第3期293-294,共2页
The Practical Journal of Cancer
