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原发性高血压患者动态脉压与肾损害的关系

Relationship between dynamic pulse pressure and renal damage in patients with essential hypertension.
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摘要 目的:探讨原发性高血压患者动态脉压与肾损害的关系。方法:对60例原发性高血压患者进行动态血压监测,按动态脉压分为脉压〉60mmHg组(PP1组)30例和脉压在40~60mmHg之间组(PP2组)30例,并测定两组患者的血、尿β2-微球蛋白(β2-MG)、尿微量白蛋白(mAlb)及血尿素氮(BUN)、肌酐(Cr)。比较两组24h血压动态参数及血、尿β2-MG、尿mAlb、血BUN、Cr。结果:脉压〉60mmHg组(PP1组)上述肾功能指标较脉压在40~60mmHg之间组(PP2组)升高(P〈0.01)。结论:原发性高血压患者肾损害与脉压增大有关。 Objective: To investigate the relationship between dynamic pulse pressure and renal damage in essential hypertension. Methods: Sixty essential hypertensive patients were divided into two groups according to the levels of ambulatory pulse pressure(PP). PP〉60mmHg (PP1 group) and 40mmHg ≤ PP ≤60mmHg (PP2group). Ambulatory blood pressure monitoring, the serum and urine β2- MG, urine mAlb, blood BUN and Cr were measured in both groups and compared between two groups. Results: Compared with PP2 group, the PP1 group showed higher levels of renal function indexes (P〈0. 01). Conclusion: Renal damage is related to pulse pressure in senile essential hypertension.
出处 《陕西医学杂志》 CAS 北大核心 2006年第8期945-946,956,共3页 Shaanxi Medical Journal
关键词 高血压/并发病 肾功能衰竭 @动态脉压 血压测定 Hypertension/complications Kideney failure @Ambulatory pulse pressure determination
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参考文献4

  • 1Staley S, Flanklin MD, Shehzad A, et al. Is pulse pressure useful in predictingrisk for coronary heart disease? the frarninyham heart study. Circulation,19993 100:354
  • 2Cuspidi C,Macca G, Sampieri L,et al. Target organ damage and non-dipping pattern defined by two sessions of ambulatory blood pres-sure monitoring in recently diagnosed essential hypertensive patients. J Hypertens, 2001 , 19:1539
  • 3Michael D, James N,Michael W,et al. Cardiovascular risk assessment using pulse pressure in the first national health and nutrition exami-nation survey. Hypertension, 2001 , 10 : 793
  • 4Dstan HP. Hpertension. JACC, 2000, 35 (Suppl 131) 1011

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