摘要
目的：研究孕妇血清透明质酸（ＨＡ）含量及雌二醇（Ｅ２）、孕酮（Ｐ）比值（Ｅ２／Ｐ）的变化，探讨其与分娩发动的关系。方法：用放射免疫分析法测定不同孕期及临产时孕妇血清Ｅ２、Ｐ及Ｅ２／Ｐ和ＨＡ含量。结果：Ｅ２、Ｐ及Ｅ２／Ｐ随孕周增长而增长，临产时达高峰；ＨＡ含量在整个孕期及临产前与非孕期水平相似，临产时增高近２倍，产后２～３天迅速下降至非孕时水平；ＨＡ含量与潜伏期时限呈负相关（ｒ＝－０．３４４，Ｐ＜０．０５）；Ｅ２／Ｐ临产前后相差显著（Ｐ＜０．０５）。结论：ＨＡ、Ｅ２、Ｐ以及Ｅ２／Ｐ在分娩发动过程中起重要的调节作用。
Objective:Tostudythechangesofserumhyaluronicacid(HA)levelandestradiol(E)toprogesterone(P)ratioduringpregnancyandtheirrelationshipwithonsetoflabour.Meth-ods:116normalpregnantwomenwithdiferentgestationageanddiferentphasesinlabourand20postpartumwomenwerestudiedwith30casesofnonpregnantwomenascontrol.ConcentrationofHA,E2andPweredeterminedbyradioimmunoassay.Results:SerumconcentrationofE2、Pandtheirratioincreasedgradualyduringpregnancyandreachedtheirpeaksattheonsetoflabour.HAconcentrationwassimilartononpregnantwomenduringfirstandsecondtrimester,however,signifi-cantlyincreasedduringlabour,andthendecreasedrapidlytononpregnantlevelat2～3dayspostpar-tum;concentrationofHA,E2,PandE2/Pincreasedsignificantlyduringlabourbutunrelatedtothegestationalagewhenlabourbegan;serumconcentrationofHAwasnegativelycorelatedwiththela-tentphase(r=-0.344,P<0.05)butnotwiththeactivephase.Conclusion:HA,E2,PandE2/Pmayplayanimportantroleintheinitiationoflabourandmaybeofvalueinevaluatingcervicalripen-ingandfacilitatinglabourmanagement.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1996年第8期477-479,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
透明质酸
孕酮
雌二醇
分娩
HyaluronicacidProgesteroneEstradiollabor
