摘要
通过动态观察消炎痛、伊曲康唑治疗前后急性胰腺炎(AP)模型大鼠血浆血栓素A_2(TXA_2)水平、胰腺血供、胰腺微循环功能状况与病理改变,探讨其内在联系。结果提示:局部缺血和微血管壁通透性增加是AP的早期病生改变,介导AP由水肿型向出血坏死型转变;AP时大量生成的TXA_2是这一病理生理改变的重要介质。为AP治疗提供了一定的理论基础。
The dynamic changes of plasma levels of TXB_2, blood supply, capillary permeability and histologic changes of pancreas were measured in AP model of rats before and after the treatment with indomethacin and itraconazale. The relationship among them was investigated. The results suggest that ischemia and the increase in capillary permeability were the early stages of AP with the key factor being TXA_2。The study provided some theoretical basis for the treatment AP.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1996年第5期257-258,共2页
Chinese Journal of Experimental Surgery
关键词
胰腺炎
微循环
微血管壁通透性
血栓素A2
acute pancreatitis
microcirculation
capillary permeabilily
thromboxane A_2
