摘要
目的:比较噻萘普汀与帕罗西汀的抗抑郁效果及不良反应。方法:随机将60例心境障碍(抑郁发作)的患者分为噻萘普汀组和帕罗西汀组各30例。疗程6周。在治疗前及治疗1、2、4、6周评定汉密尔顿抑郁量表(HAMD,17项),并记录不良反应。结果:噻萘普汀组从治疗2周HAMD评分开始显著下降,而帕罗西汀组从治疗1周就开始显著下降;治疗6周噻萘普汀有效率90.0%,显效率73.3%,帕罗西汀组分别为90.0%和80.0%。两组患者的不良反应相仿。结论:噻萘普汀和帕罗西汀治疗抑郁症疗效相当,不良反应少。
Objective： To compare the efficacy and safety of tianeptine and paroxetine in the treatment of depression. Method：Sixty patients with depression were randomly divided into tianeptine group（ n = 30）and paroxetine group（ n = 30） and received treatment for 6 weeks. HAMD were used to assess the efficacy before treatment and after treatment for 1,2,4,6 weeks. Results： There was no significant difference in efficacy between two groups. HAMD scores decreased dramatically at the end of 2nd week in tianeptine group and 1st week in paroxetine group. The rotes of efficacy and marked improvement in tianeptine group and paroxetine group were 90.0% and 73.3% , 90.0% and 80.0% respectively. Conclusion：It is suggested that both tianeptine and paroxetine are effective in the treatment of depression, with mild side effects.
出处
《临床精神医学杂志》
2006年第4期219-220,共2页
Journal of Clinical Psychiatry
