摘要
目的：回顾性分析总结益气活血化湿方案为主治疗膜性肾病的临床疗效。方法：收集1990年～2005年间以“益气活血化湿方案”为主治疗的膜性肾病170例，其中单纯采用益气活血化湿中药治疗的70例（列为中药组），益气活血化湿方案联合免疫抑制剂治疗的100例（列为中西医结合组），对两组进行分析比较，观察治疗前后24h尿蛋白定量、血浆白蛋白、肾功能的变化。结果：统计分析表明，治疗1年、2年及4年以上的总有效率分别为90．20％、91．43％和92．86％，4年以上的完全缓解率为71．43％。进一步分析发现中药组能显著减少尿蛋白排泄量及升高血浆白蛋白水平（与治疗前相比P=0．000），其作用与中西医结合组无统计学差异（P〉0．05）。对170例膜性肾病中的128例肾病综合征进行分析，中药组（49例）总有效率为85．71％，中西医结合组（79例）为82．28％，两组相比无统计学差异。结论：益气活血化湿方案具有疗效确切而巩固、复发率低等显著优势。
Objective：To summarize and analyze the therapeutic effect of Yiqi Huoxue Huashi Project for patients with membranous nephropathy. Methods： One hundred and seventy MN patients were divided into two groups. Seventy-nine patients in Chinese herb group were treated with ＂Yiqi Huoxue Huashi Project＂ alone. One hundred patients in the control group were treated with integrated Chinese- Western therapy （＂Yiqi Huoxue Huashi Project＂ combining with Immunosuppressive agents）. Results：The total effective rate at 1,2,4 - year was 90.20%, 91.43% and 92.86%, respectively. The complete remission rate for more than 4 years was 71.43%. ＂Yiqi Huoxue Huashi Project＂ reduced urinary protein excretion and increased plasma albumin level, without significant differences compared with control group. The analysis of 128 cases of nephrotic syndrome patients showed that the total effective rate in Chinese herbs group（49 cases） reached 85.71%, without significant difference compared with control group（ 79 eases） which reached 82.28 %. Conclusion：The therapeutic effect of ＂Yiqi Huoxue Huashi Project＂ is definite, with low relapse rate and no side effect. Chinese herbs play an important role in the treatment of intractable nephrotic syndrome.
出处
《中国中西医结合肾病杂志》
2006年第8期393-396,共4页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
上海市卫生局中医药特色诊疗项目(No.2004T001A)
关键词
膜性肾病
益气活血化湿
中医药疗法
Membranous nephropathy Yiqi Huoxue Huashi Project Therapy of traditional Chinese medicine
