摘要
Inflammatory bowel diseases, ulcerative colitis, and Crohn＇s disease, are chronic intestinal disorders of unknown etiology in which in genetically susceptible individuals, the mucosal immune system shows an aberrant response towards commensal bacteria. The gastrointestinal tract has developed ingenious mechanisms to coexist with its autologous microflora, but rapidly responds to invading pathogens and then returns to homeostasis with its commensal bacteria after the pathogenic infection is cleared. In case of disruption of this tightly-regulated homeostasis, chronic intestinal inflammation may be induced. Previous studies showed that some commensal bacteria are detrimental while others have either no influence or have a protective action. In addition, each host has a genetically determined response to detrimental and protective bacterial species. These suggest that therapeutic manipulation of imbalance of microflora can influence health and disease. This review focuses on new insights into the role of commensal bacteria in gut health and disease, and presents recent findings in innate and adaptive immune interactions. Therapeutic approaches to modulate balance of intestinal microflora and their potential mechanisms of action are also discussed.
煽动性的肠疾病， ulcerative，和 Crohn 是疾病，是在的未知病原学的长期的肠的混乱在遗传上易受影响的个人，，粘膜免疫系统向共栖的细菌显示出异常回答。胃肠道开发了机灵的机制与它的自体同源的微植物群共存，但是在病原的感染被清除以后，很快对与它的共栖的细菌入侵病原体然后回来到动态平衡作出回应。在这紧调整的动态平衡的混乱的情况下，长期的肠的发炎可以被导致。当其它也没有影响或有一个保护的行动时，以前的研究证明一些共栖的细菌是有害的。另外，每位主人有遗传上坚定的回答到有害、保护的细菌的种类。这些建议微植物群的不平衡的那治疗学的操作能影响健康和疾病。这评论处于内脏健康和疾病集中于新卓见进共栖的细菌的角色，并且在天生、适应的有免疫力的相互作用介绍最近的调查结果。调制肠的微植物群的平衡和他们行动的潜在的机制的治疗学的途径也被讨论。
