摘要
目的与传统Child-Turcotte-Pugh(CTP)评分及晚近终末期肝病的危险度评分模型(modelforend-stageliverdisease,MELD)评分比较,探讨无创定量超声评分评估肝纤维化程度的可能性。方法对53例肝纤维化患者及25例健康对照者进行经皮肝穿刺活体组织病理检查、超声检查及各项临床指标检查,以病理诊断结果为标准,计算CTP及MELD评分,并参考相关文献建立无创定量超声评分标准,探讨超声评分对肝纤维化无创定量诊断的价值。结果肝纤维化患者超声评分与病理学肝纤维化分期相关性良好,超声总评分与病理分期相关系数为0.860(P<0.01);超声总评分与临床CTP及MELD评分相关性良好,相关系数为0.784及0.768(P<0.01);超声、CTP、MELD评分3种方法结合使用,诊断肝纤维化的敏感性96.7%,特异性95.5%。结论应用超声评分法无创诊断肝纤维化有较高的临床价值。
Objective To investigate the possibility of evaluation hepatic fibrosis by noninvasive quantitative ultrasonographic score, comparing child-turcotte-pugh （CTP） with model for end-stage liver disease （MELD）. Methods Fifty-three patients confirmed by biopsy and 25 healthy persons were examined with ultrasonographic and clinical parameters. CTP and MELD scores were calculated as the standard of pathology. The ultrasonographic quantitative score system was established according to the previous research. Results The ultrasonographic quantitative score was related to pathological hepatic fibrosis stage（ r = 0. 860, P -〈0.01 ）. There was good relation between quantitative ultrasonographic score and clinical CTP or MELD scores （ r = 0. 784, 0. 768, respectively, P -〈0.01）. Using ultrasonography combined CTP and MELD would have high diagnostic sensitivity and specialty on hepatic fibrosis（96.70%, 95.5%, respectively）. Conclusions Ultrasonographic quantitative score system has higher clinical value for noninvasive diagnosis of hepatic fibrosis.
出处
《中华超声影像学杂志》
CSCD
2006年第8期588-590,共3页
Chinese Journal of Ultrasonography
