摘要
目的对比观察时辰化疗联合动脉化疗、动脉化疗与常规化疗三者对口腔颌面部鳞癌的疗效和毒副作用。方法95例口腔鳞癌患者,随机分为时辰化疗联合动脉化疗组32例,动脉化疗组32例,常规化疗组31例。比较卡铂联合5-Fu化疗2个疗程后三组的疗效和毒副作用。结果联合组和动脉化疗组的疗效都显著高于常规组(P<0.1);联合组和动脉化疗组的毒副作用发生率都显著低于常规组(P<0.05)。结论利用卡铂联合5-Fu作为化疗方案的时辰化疗联合动脉化疗治疗口腔颌面部鳞癌可提高疗效,减少毒副作用,值得临床推广。
Objective To investigate the therapeutic effects and toxicities of arterial chrono-chemotherapy, arterial chemotherapy and routine chemotherapy using carboplatin （CBP） and 5-fluorouracil （ 5-FU ） for the patients with oral squamous cell carcinoma （OSCC）. Methods A total of 95 patients with OSCC were randomly divided into three groups ： arterial chrono-chemotherapy group （group Ⅰ , 32 cases）, arterial chemotherapy group （group Ⅱ, 32 cases） and routine chemotherapy group （group Ⅲ,31 cases）. Therapeutic effects and side effects among the three groups were studied after two chemotherapy courses. Results The effective rate of group Ⅰ and group Ⅱ was significantly higher than that of group Ⅲ （ P 〈 0.1 ） ; Toxicity incidence rates of group Ⅰ and group Ⅱ were significantly lower than that of group Ⅲ （ P 〈 0. 05）. Conclusion Arterial chrono-chemotherapy of CBP and 5-FU for the patients with OSCC can increase therapeutic effects and reduce toxicities comparing with routine chemotherapy.
出处
《北京口腔医学》
CAS
2006年第3期192-194,共3页
Beijing Journal of Stomatology
关键词
时辰化疗
动脉化疗
鳞癌
口腔颌面部
Chrono-chemotherapy
Arterial chemotherapy
Squamous cell carcinoma
Oral and maxillofacial region
