摘要
目的研究高通量血液透析器(HPD)对尿毒症病人β2-微球蛋白(β2-MG)的清除作用,为预防透析相关性淀粉样变性寻求新的治疗途径提供临床依据。方法维持性血液透析病人38例随机分为2组,全部进行常规血液透析:一组采用FreseniusF60高通透性透析器(HPD),另一组采用FreseniusF6低通透性透析器(CHD)。透析时间均为4h,透析前后抽血检测血清β2-MG。结果HPD组透析后血β2-MG明显下降(P<0·01),CHD组透析前后血β2-MG无明显变化(P>0·05),组间比较透析后HPD组血β2-MG明显低于CHD组(P<0·01)。结论HPD对β2-MG具有明显的清除作用。
Objective To compare the clearance of β2-Micruglobulin in hemodialysis patients with highly permeable dialyzer （HPD） and conventional hemodiayzer（CHD） , and verify the clearance of middle and large molecular substance with HPD. Methods Thirty eight patients receiving maintenance bemodialysis were chosen. They were divided into two groups with different dialyzer：experimental group HPD with F60 filter and control group CHD with F6 dialyzer. β2-MG were measured before and after dialysis by Enzyme Linked Immunosorbent Assay（ELISA）. Results The level of β2-MG in patients＇serums is lowed significantly after dialysis in HPD group（P 〈 0. 01 ）. There is no difference in CHD group（ P 〉0. 05 ）. The decreasing rate of β2-MG in HPD group is higher than that in control group after dialysis（ P 〈0. 01 ）. Conclusions HPD can clear β2-MG effficiently,and there is no significant decrease in β2-MG in CHD.
出处
《中国厂矿医学》
2006年第4期298-299,共2页
Chinese Medicine of Factory and Mine
