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鼻息肉的药物治疗 被引量:1

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摘要 鼻息肉的典型组织形态学特征为嗜酸性粒细胞集聚及结缔组织毁损。目前局部和全身用皮质类固醇是鼻息肉药物治疗的首选。如果药物治疗失败,则为手术适应证,但术后常需要药物维持。用其他药物经验很少,如抗组胺药、白三烯拮抗剂和呋塞米,一般加在皮质类固醇治疗的部分病人中。对皮质类固醇或手术无反应者用阿司匹林脱敏疗法是一种选择。近来新的治疗途径是,使用特定靶向嗜酸性粒细胞聚集(趋化因子受体3,eotaxin)、炎症(白细胞介素-4,-5,-13)和免疫球蛋白E的药物,或者用降低金属蛋白酶活性的药物以减轻组织重构。
作者 朱东屏
出处 《国外医学(药学分册)》 2006年第4期252-254,共3页 Foreign Medical Sciences(Section of Pharmarcy)
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同被引文献13

  • 1赵绪韬.鼻息肉的治疗进展[J].世界临床药物,2006,27(7):417-422. 被引量:5
  • 2吴敏曼,孙虹.鼻息肉复发的防治[J].国际耳鼻咽喉头颈外科杂志,2006,30(4):259-262. 被引量:13
  • 3白永,李娜,张念凯.阿奇霉素对慢性鼻窦炎鼻息肉患者术腔黏膜上皮化的影响[J].山东大学耳鼻喉眼学报,2006,20(5):413-415. 被引量:6
  • 4Hissaria P , Smith W ,Wormald PJ, et al. Short course of systemic corticosteroids in sinonasal polyposis: a double-blind, randomized, placebo-controlled trial with evaluation of outcome measures [J]. Allergy Clin Immunol,2006,118(1):128-133
  • 5Small C B ,Hernandez J ,Reyes A ,et al. Efficacy and safety of mometasone furoated nasal spray in nasal polyposis [J].Allergy Clin Immunol,2005,116 (6):1275-1281
  • 6Sieskiewiez A, Olszewska E, Rogowski M, et al. preoperative corticosteroid oral therapy and intraoperative bleeding during functional endoscopic sinus surgery in patients with severe nasal polyposis:a preliminary investigation [J]. Ann Otol Rhinol laryngol, 2006,1157(7):490-494
  • 7Benitez P ,Alobid I, de Haro J, et al. A short course of oral prednisone followed by intranasal budesonide is an effective treatment of severe nasal polyps[J].Laryngoscope,2006,116(5):770-775
  • 8Alobid I, Benitez P, Pujols L, et al. severe nasal polyposis and its impact on quality of the effect of a short course of oral steroids followed by long term intranasal steroid treatment [J]. Rhinology,2006,44(1):8-13
  • 9Kuran G , Kocaturk S, Kurukahvecioglu S, et al. The efficacy of combined medical treatment (antihistaminics steroids and macrolide antibiotics) in patients with nasal polyposis: preliminary results [J].Journal of Ear, Nose and Throat ,2002,9(5):252-257
  • 10Bonfils P, Halimi P, Malinvaud D. Adrenal suppression and osteoporosis after treatment of nasal polyposis[J]. Acta Otolaryngol,2006,126(11):1195-1200

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