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基因治疗与角膜移植免疫耐受

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作者 张永强 陆晓和
机构地区 南方医科大学珠江医院眼科
出处 《广东医学》 CAS CSCD 北大核心 2006年第9期1413-1415,共3页 Guangdong Medical Journal
基金 广东省自然科学基金资助项目(编号:04020438)
关键词 高危角膜移植 基因治疗技术 移植免疫耐受 术后免疫排斥反应 移植免疫排斥反应 异体角膜移植 手术失败 免疫学技术 分子生物学 器官移植
分类号 R779.65 [医药卫生—眼科] R456 [医药卫生—治疗学]
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参考文献20

  • 1WILLIAMS K A,JESSUP C F,COSTER D J.Gene thetapy approaches to prolonging corneal allograft survival[J].Expert Opin Biol Ther,2004,4(7):1059-1071.
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  • 4COMER R M,KIGN W J,ARDJOMAND N,et al.Effect of administration of CTLA4-Ig as protein or cDNA on corneal allngraft survival[J].Invest Ophthalmol Vis Sci,2002,43(4):1095-1103.
  • 5ZHANG E P,FRANKE J,SCHROFF M,et al.Ballistic CTLA4 and IL-4 gene transfer into the lower lid prdongs orthhotopic corneal graft survival in mice[J].Graefes Arch Clin Exp Ophthalmol,2003,241(11):921-926.
  • 6NICKERSON P,STEIGER J,ZHENG X X,et al.Manipulation of cytokine networks in transplantation[J].Transplantation,1997,63(4):489-494.
  • 7JESSUP C F,BRERETON H M,SYKES P J,et al.Local gene transfer to modulate rat comeal allograft rejection[J].Invest Ophthalmol Vis Sci,2005,46(5):1675-1681.
  • 8SAKAI R,YAMAGAMI S,INOKI T,et al.Th1/Th2-balance in anterior chamber-associated immune deviation by alloantigen[J].Graefes Arch Clin Exp Ophthalmol,2002,240(2):154-159.
  • 9KLEBE S,SYKES P J,COSTER D J,et al.Prolongation of sheep corneal allograft survival by exvivo transfer of the gene encoding interleukin-10[J].Transplantation,2001,71(9):1214-1220.
  • 10KLEBE S,COSTER D J,SYKES P J,et al.Prolongation of sheep corneal allograft survival by transfer of the gene encoding ovine IL-12-p40 but not IL-4 to donor corneal endothelium[J].J Immunol,2005,175(4):2219-2226.

二级参考文献38

  • 1[1]Williams KA,Muehlberg SM,Lewis RF,Coster DJ. How successful is corneal transplantation-a report from the Australian corneal graft register[J].Eye 1995;9(pt2): 219-227.
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共引文献17

广东医学
2006年 第9期

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