摘要
目的制备姜桂pH依赖型梯度释药胶囊并进行释放度考察。方法分别以HPMC,EudragitL100-55和Eudragit L100为包衣材料制备pH依赖型梯度释药微丸后制成胶囊,并进行体外释放度研究。结果所制备的3批胶囊的pH分别在1.0,5.5和6.8梯度释药,指标成分桂皮醛和二苯基庚烷A释放度的f 2值分别为72.1,69.3和73.9。结论缓释胶囊中桂皮醛和二苯基庚烷A能同步释放,具有pH依赖型释药的特征。
Objective To prepare Jiang-Gui pH dependent gradient-release capsules and investigate the drug release. Methods The pH dependent gradient -release capsules were prepared by three pellets which coated with HPMC, Eudragit L100- 55 and Eudragit L100. The release profile of the pH dependent gradient-release system was determined in vitro. Results The result showed that the release of cinnamldehyde and diarylheptanoid A from capsules complied with the simulated gastrointestinal pH conditions. The f 2 value of release profile of cinnamldehyde and diarylheptanoid A were similar. Conclusion The cinnamldehyde and diarylheptanoid A from pH dependent gradient-release capsules can release simultaneously, and the capsules bane the characteristics of pH dependent gradient-release in gastrointestinal tract.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2006年第8期1421-1422,共2页
Lishizhen Medicine and Materia Medica Research
基金
广东省自然科学基金资助项目(No.04009618)
关键词
复方中药
pH依赖型梯度释药系统
姜桂胶囊
Traditional Chinese medicine compound recipe
pH dependent gradient-release system
Jiang-Gui Capsules
