摘要
“血瘀辩证药动学”指的是血瘀证的病理生理状态对药动学参数有显著影响。为了验证这一新假说，我们选择冠状动脉定量狭窄（心血瘀阻）动物和磷酸川芎嗪作为工具模型和工具药，同步观察了川芎嗪在对照和动物模型组的药动学和血流动力学。与对照组比较，模型组的川芎嗪血清浓度、血药浓度时间曲线下面积值和ｔ１／２β增高（Ｐ＜０．０１）；其可能机理与冠状动脉狭窄诱导的血流动力学异常有关。
Blood stasis syndrome pharmacokinetics'means the pathophysiological state of blood stasis syndrome affectes significantly the pharmacokinetic parameters.In order to provide scientific evidence for the new hypothesis,the authors studied the hemodynamic changes induced by quantitative coronary artery stenosis and pharmacokinetics of tetramethylpyrazine(TMP) in dog model with heart blood stasis(HBS) and in normal dog(for control) simultaneously.Compared with healthy dog,serum TMP concentration,drug concentration time, area under curve(AUC) and t1/2β in HBS dog were increased signficantly(p<0.01).The mechanism might be related with the abnormal changes in hemodynamics(include decrease in cardiac output,left ventricular systolic pressure and coronary blood flow, etc.) caused by coronary artery stenosis.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1996年第6期352-354,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金
关键词
冠状动脉狭窄
川芎嗪
药物动力学
心血淤阻
犬
quantitative coronary stenosis,animal model,tetramethylpyrazine phosphate,heart blood stasis,pharmacokinetics,hemodynamics
