摘要
动脉再狭窄严重影响了经皮腔内冠状动脉成形术（ＰＴＣＡ）的远期疗效。为评价丹参用于防治再狭窄的可能性，本研究利用大鼠动脉再狭窄模型，观察了丹参对动脉去内皮后内膜增生的影响，并观察了丹参注射液对离体培养的兔动脉平滑肌细胞（ＳＭＣ）增殖的影响。结果表明，丹参注射液在体外抑制培养的ＳＭＣ增殖，在体内抑制动脉去内皮后的内膜增生，提示丹参有望成为防治再狭窄的有效药物。
Eor evaluating the possibility of Salvia miltiorrhiza(SM) on the prevention of arterial restenosis after angioplasty, we investigated the effect of SM on the intimal thickening of air-injured carotid artery of rats. The results showed that the maximal intimal thickness of the injured arteries was much thinner in the treatment group than that in the control group, indicated that SM could prevent experimental restenosis in rat model. Furthermore, we examined the effect of SM on the proliferation of the isolated rabbit artdrial smooth muscle cells (SMC) cultivated in vitro. The results showed that SM inhibited the ￣3H-TdR take-up and proliferation of SMC in a dose-dependent manner. The study raised the possibility that SM could be used to prevent arterial restenosis after angioplasty.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1996年第8期480-482,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
丹参注射液
再狭窄
动脉疾病
中医药疗法
Salvia miltiorrhiza injection, smooth muscle cell, restenosis
