摘要
目的评价X线三维适形放疗(3DCRT)并同期吉西他滨(泽菲)化疗综合治疗Ⅲ期老年非小细胞肺癌(NSCLC)的疗效及毒副作用。方法65例Ⅲ期老年非小细胞肺癌(NSCLC)患者随机分为2组:治疗组35例,行全程X线三维适形放疗DT(40～52)Gy/(3～4)周,(3～4)Gy/次,5次/周;化疗,泽菲1000mg/m2,每周1次,连3周(第1、8、15天静点)。对照组30例,只行三维适形放射治疗,具体剂量、分割方式同治疗组。治疗完成后评价疗效和不良反应。结果治疗组总有效率(CR+PR)74.29%,完全缓解率(CR)22.85%;对照组总有效率50.00%,完全缓解率10.00%,两组间总有效率差异有显著性(χ2=4.09,P=0.043)。中位生存期治疗组和对照组分别为13个月和11个月,1、2年生存率治疗组分别为60%、33.33%;对照组分别为50%、23.33%,两组间差异无显著性(P>0.05)。放化疗的毒副反应主要是消化道反应、骨髓抑制、放射性肺炎和放射性食管炎,但皆可耐受。结论全程X线三维适形放疗并同期泽菲化疗综合治疗Ⅲ期老年非小细胞肺癌(NSCLC)可明显提高近期疗效,远期疗效略有提高,但无统计学差异,值得进一步研究。
Objective To evaluate the therapeutic effectiveness and adverseevents of concurrent gemcitabine chemotherapy and 3-dimentional conformalradiotherapy （3D-CRT） for elderly advanced non-small cell lung cancer（NSCLC）. Methods 65 patients of stage Ⅲ NSCLC were enrolled into twogroups： 35cases in the treatment group received concurrent chemotherapy（gemcitabine 1000mg/m^2/w, continuous 3 weeks） and 3D-CRT： were given, （3-4）Gyper fractions,5 fraction a week, to total dose of （40- 52 ） Gy/（3 - 4） week. 30 casesin the control group received 3D-CRT alone （3 -4） Gy per fraction, 5 fractions a week,to total dose of （40-52）Gy/（3-4） week. Results The overall responserate （CR＋ PR） in the treatment group was 74. 29% with a complete response rate（CR） 22. 85%. The overall response rate （CR ＋ PR） in the control group was 50. 00% with a complete response rate （CR）10. 00%. The difference of overallresponse rate between two groups was statistically significant （P〈0. 05）. The median survival time, 1-, 2-year survival rates were 13months, 60. 00 %, 33. 33 % for the treatment group, and 11 monthts, 50% ,23.33% for thecontrol group （P〉0. 05） respectively. The incidence of radiation pneumonitisand esophagitis is not different（P〉0. 05） between the treatment group and inthe control group. The toxic effects can be tolerable by all patients. Conclusion There is better overall response？？ rate in the concurrentchemo-radiotherapy group than in the 3D-CRT alone group. The toxic effectssuch as pneumonitis and esophagitis can be tolerable. The concurrentgemcitabine chemotherapy and 3-dimentional conformal radiotherapy is bettertreatment method for elderly advanced NSCLC.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2006年第8期596-598,共3页
Cancer Research on Prevention and Treatment
关键词
非小细胞肺癌
三维适形放疗
化疗
同期放化疗
Non-small cell lung cancer
Gemcitabine
3D-CRT
Concurrentchemo-radiotherapy
