摘要
目的探讨食管鳞癌缺氧诱导因子1α(HIF1α)的表达与放疗疗效的关系。方法采用免疫组织化学SP法检测食管镜活检50例有完整随访资料的接受外照射治疗的食管鳞癌中HIF1α蛋白的表达。结果50例食管鳞癌放疗近期有效率为86%。HIF1α主要表达于食管鳞癌细胞的细胞核,其阳性表达率为68%;HIF1α表达阳性和阴性组食管癌患者的放疗后近期完全缓解率、中位生存时间及95%的可信区间分别为18.75%、10(7.86,12.14)个月和81.25%、25(15.57,34.43)个月,HIF1α阳性表达组的放疗后缓解率、生存期明显小于阴性组(P<0.05)。HIF1α的表达与病理类型无明显关系(P>0.05)。与临床分期有关,I～II、III～IV期HIF1α阳性表达率分别为11.11%、78.05%,两者差异具有显著性(P<0.05)。多因素COX模型逐步回归分析结果显示“临床分期”、“病变长度”和“HIF1α”3种因素对患者生存期的影响最大。结论HIF1α蛋白阳性表达是食管癌患者预后不良的标志,其高表达与食管癌的放射抗拒性有密切关系。
Objective To explore the prognostic importance of hypoxia inducible factor-1α（HIF-1α） expression in esophageal squamous cell carcinoma （ESCC）. Methods The expression of HIF-1α was detected by immunohistochemical staining （SP）in fifty patients with ESCC received radiatherapy. Results HIF-1α was expressed in the nucleus of tumor cells in 34/50 （68%） cases with ESCC. The complete ef- fective rate to radiotherapy and median survival periods and 95 confidence interval of those with positive expression of HIF-1α and with negative expression were 18. 75%, 10 （7. 86, 12. 14） and 81.25%, 25 （15.57,34. 43）months, respectively. Patients with positive expression obviously survived less than those with negative expression and the difference was significant （P〈0. 05）. The positive rate of HIF-1αwas closely re1αted to clinical stage （P〈0. 05） and no corre1αtion with the differentiation degree of tumor （P 〉0. 05）. Conclusion The expression of HIF-1α may serve as important parameter in evaluating response for radiotherapy and prognosis of ESCC.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2006年第8期602-604,共3页
Cancer Research on Prevention and Treatment
基金
河北省科技厅科技攻关课题(052761764)
关键词
食管肿瘤
缺氧诱导因子-1
免疫组织化学
放射治疗
预后
Esophageal squamous cell cancer（ESCC）
Hypoxia Inducible Factor 1α（ HIF-1α）
Radiotherapy
Prognosis
