水孔蛋白-4及其表达变化在脑水肿中的作用
摘要
本文介绍了水孔蛋白4在结构、分布以及定位方面的最新研究成果,分析文献,指出水孔蛋白4既参与水肿的形成,又参与水肿的消退;它的表达变化是组织缺氧、内环境紊乱及血脑屏障破坏的结果,对机体既有保护作用,也产生损害;同时提出一种新的治疗脑水肿的设想。
出处
《国际神经病学神经外科学杂志》
2006年第4期353-356,共4页
Journal of International Neurology and Neurosurgery
参考文献25
-
1Itoh T,Rai T,Kuwahara M,et al.Identification of a novel aquaporin,AQP12,expressed in pancreatic acinar cells.Biochem Biophys Res Commun.2005,330 (3):832-838.
-
2Neely JD,Amiry-Moghaddam M,Ottersen OP,et al.Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein.Proc Natl Acad Sci U S A.2001,98(24):14108-14113.
-
3Rash JE,Davidson KG,Yasumura T,et al.Freeze-fracture and immunogold analysis of aquaporin-4 (AQP4) square arrays,with models of AQP4 lattice assembly.Neuroscience.2004,129(4):915-934.
-
4Silberstein C,Bouley R,Huang Y,et al.Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells.Am J Physiol Renal Physiol.2004,287(3):F501-511.
-
5Hiroaki Y,Tani K,Kamegawa A,et al.Implications of the aquaporin-4 structure on array formation and cell adhesion.J Mol Biol.2006,355(4):628-639.
-
6Amiry-Moghaddam M,Xue R,Haug FM,et al.Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia.FASEB J.2004,18 (3):542-544.
-
7Cavazzin C,Ferrari D,Facchetti F,et al.Unique expression and localization of aquaporin-4 and aquaporin-9 in murine and human neural stem cells and in their glial progeny.Glia.2005,53(2):167-181.
-
8Tomas-Camardiel M,Venero JL,Herrera A J,et al.Bloodbrain barrier disruption highly induces aquaporin-4 mRNA and protein in perivascular and parenchymal astrocytes:protective effect by estradiol treatment in ovariectomized animals.J Neurosci Res.2005,80(2):235-246.
-
9Nicchia GP,Nico B,Camassa LM,et al.The role of aquaporin-4 in the blood-brain barrier development and integrity:studies in animal and cell culture models.Neuroscience.2004,129(4):935-945.
-
10Amiry-Moghaddam M,Frydenlund DS,Ottersen OP.Anchoring of aquaporin-4 in brain:molecular mechanisms and implications for the physiology and pathophysiology of water transport.Neuroscience.2004,129(4):999-1010.
-
1谭殿辉,赖润龙,喻小萍,李勇,张填波,周晓斌.大鼠去骨瓣减压术后水孔蛋白-4表达变化的实验研究[J].中国医学创新,2013,10(28):22-25. 被引量：2
-
2田力,申明惠,王佳贺,张萌,张威,高岩,滕伟禹.抑肽酶对大鼠实验性脑出血后AQP4mRNA表达及脑水肿的作用[J].中国医学工程,2008,16(3):161-163. 被引量：1
-
3田力,张萌,刘海峰,滕伟禹.实验性脑出血后水孔蛋白-4水平的变化及阿加曲班的干预作用[J].中国现代医学杂志,2009,19(22):3392-3394.
-
4周敬华,曹学兵,孙圣刚.脑出血大鼠血肿周围组织水孔蛋白-4表达分析[J].中国神经免疫学和神经病学杂志,2006,13(4):230-233. 被引量：2
-
5李慧,陈吉相.地塞米松对脑出血大鼠脑AQP4影响的研究[J].现代实用医学,2007,19(9):690-693. 被引量：2
-
6周敬华,曹学兵,孙圣刚.精氨酸加压素对星形胶质细胞水孔蛋白-4表达的调节及脑水肿形成影响的研究[J].中风与神经疾病杂志,2008,25(5):567-569. 被引量：5
-
7王开霞,刘斌.女性脑梗死患者颈动脉粥样硬化斑块与性激素水平的相关性研究[J].中国综合临床,2006,22(8):754-755. 被引量：1
-
8唐志洪.糖尿病并发脑卒中的临床特点[J].医学理论与实践,2001,14(12):1204-1205. 被引量：1
-
9周保健,袁宝强.癫发作后神经发生中HIF-1α的作用[J].徐州医学院学报,2010,30(6):409-411. 被引量：1
-
10宋波.水孔蛋白-4与脑水肿[J].国外医学（神经病学．神经外科学分册）,2003,30(2):116-119. 被引量：4
