摘要
目的研究β-受体阻断剂倍他乐克对老年冠心病(CAD)患者QT间期离散度(QTd)的影响。方法采用前瞻、随机、对照的方法,将76例老年冠心病(CAD)患者分为试验组(38例)和对照组(38例),对照组接受常规治疗,试验组在常规治疗基础上加服倍他乐克,观察两组治疗前、后QTd及RR间期、心律校正QT间期离散度(QTcd)、最大QT间期(QTmax)、最小QT间期(QTmin)的变化。结果试验组患者QTmin延长,QTd、QTcd缩短,差异均有非常显著性意义(P<0·01),而QTmax无明显改变(P>0·05)。对照组治疗前、后QTd、QTcd、QTmax、QTmin均无改变(P>0·05)。结论倍他乐克通过延长老年CAD患者QTmin缩小心肌复极化离散的程度,使心肌复极化趋向同步,防止恶性室性心律失常的发生,提高患者生活质量。
Objective To study the effect of Betaloc （ β- blockade） on the QT dispersion （QTd） in aged patients with coronary artery disease （CAD）. Methods 76 elderly patients were divided into test group （38cases） and control group （38 cases） by random. The control group was treated by general method and the test group was treated by Betaloc with general method to observe the variation of QTd, RR, QTCd, QTmax and QTmin. Results The QTd and QTcd of the treatments of patients for drugs with Betaloc were shortened （ P 〈 0. 01 ） and prolonged QTmin significantly （ P 〈0. 01 ）. But didn＇t change QTmax （ P 〈 0. 05）. Conclusion Betaloc could diminish dispersion of repolarization of ventricular myocardium in aged patients, which is beneficial for preventing malignant ventricular arrhythmias and improving life standard of patients.
出处
《实用心脑肺血管病杂志》
2006年第6期442-443,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
