摘要
目的:观察妊娠高血压综合征(PIH)患者胎盘细胞凋亡的情况。方法:采用DNA缺口原位标记Tunels’技术,测定30例PIH患者和24例正常妊娠胎盘不同部位细胞凋亡指数,并以电镜的超微结构来证实。结果:PIH组胎盘绒毛滋养细胞、合体滋养细胞、蜕膜细胞凋亡指数分别为(5.46±2.60)%(、7.48±3.90)%(、5.73±2.89)%,对照组分别为(3.95±1.75)%(、5.42±1.96)%(、4.08±1.99)%,两组相比差异均有统计学意义(P<0.01);电镜显示PIH患者胎盘绒毛滋养细胞与合体滋养细胞均有不同程度的异常形态变化。结论:细胞凋亡是PIH形成的重要因素之一,是影响胎盘功能的直接原因。
Objective：To observe the placental apoptosis in patients with pregnancy induced hypertension（PIH）.Methods： TDT- mediated DUTP nick and labeling（Tunel） technique was used for 30 human placental samples with PIH and 24 normal placental samples to determine apoptosis index in cytotrophoblast,syncytiotrophoblast and decidual cells to observe these samples under the electronic microscope.Results： The cytotrophoblast, syncytophoblast, and decidual cells in the PIH group were （5.46±2.60）%,（7.48±3.90）%, and （5.73±2.89）%, respectively. The cytotrophoblast, syncytophoblast, and decidual cells in the control group were（3.95±1.75）%.（5.42± 1.96）%,and （4.08±1.99）%,respectively.The apoptosis index in placental cytotrophoblast, syncytophoblast, and decidual cells was higher in PIH group than in the control group.The significant morphologies of apoptosis were found under the electroni cmicroscope. Conclusion：Apoptosis is a direct reason for the effect of the polacental functions and also an important factor for the critical pregnanc result in PIH.
出处
《交通医学》
2006年第4期394-395,共2页
Medical Journal of Communications
关键词
妊娠高血压综合征
细胞凋亡
胎盘
pregnancyi nduced hypertension
apoptosis
placenta
