摘要
目的：考察西藏登山队员谷胱甘肽硫转移酶（GSTs）基因多态性与高原低氧反应敏感性之间的关系。方法：采用高原-平原对照法，通过多重PCR和PCR—RFLP技术检测西藏登山队员和平原汉族人群体内谷胱甘肽硫转移酶基因多态性。结果：GSTT1缺失基因型频率在西藏登山队员和平原汉族人群中有显著性差异（P〈0．05），OR=1．86（95％CI=101～3．39）；GSTP1-105变异基因型频率差异非常显蓍（P〈0．01），OR=2．19（95％CI=1．16～4．13）．其等位基因A和G在两组人群中有显著性差异（P〈0．01）。而GSTM1缺失基因型无显著性差异（P〉0．05），OR=0．78（95％CI=0．43～1．42）。结论：GSTT1和GSTP1-105基因型可能与高原低氧反应敏感性有关。
Aim： To investigate the relationship between glutathione S-transferases gene polymorphism and susceptibility response to hypoxia. Methods： In the case-control study, the gene polymorphisms of glutathione S-transferases were tested in Tibetan mountaineers and sea-level Han Chinese by multiple-PCR and PCR-RELP. Results： The frequency of GSTT1 null genotype was significant different between Tibetan mountaineers and sea-level Han Chinese（P 〈 0.05） ,OR = 1.86 （95% CI = 1.01-3.39）, and also for GSTPI.105 mutant genotype in two groups（P 〈 0.01 ）, OR = 2.19 （95 % CI = 1.16 - 4.13）. There was significant difference between A allele and G allele of GSTP1-105 groups（P 〈 0.01 ）. There was no difference for GSTM1 null genotype between two groups （P 〉 0.05） ,OR = 0.78 （95 % CI = 0.43 - 1.42）. Conclusion ： GSTT1 and GSTPH05 genotype may be associated with susceptibility response to altitude hypoxia.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2006年第3期334-337,共4页
Chinese Journal of Applied Physiology
