摘要
目的探讨辅助生殖技术后出生儿的安全性以及畸形、死亡等原因。方法回顾分析我院2001年1月至2004年12月经体外受精(IVF)、卵胞浆内单精子注射(ICSI)后妊娠分娩的101例新生儿(观察组)与同期本院自然妊娠分娩的4,435例新生儿(对照组)比较。结果观察组新生儿的早产、低体重儿、多胎妊娠率均明显高于对照组,新生儿畸形和死亡率两组相似,产前诊断可以早期诊断治疗胎儿宫内发育异常。结论经辅助生殖技术出生儿多胎妊娠及围产儿并发症多,优生优育指导,必要的产前诊断及筛查,积极的干预有利于改善新生儿的预后及生活质量。
Objective： This study was undertaken to analyze the pregnancy outcome after assisted reproductive technology （ART）, especially the reason of fetal abnormities and fetal demise.
Methods： A total of 101 births achieved by IVF and ICSI in Guangzhou Maternal ＆Infant Hospital from January of 2001 to December of 2004 were retrospectively analyzed, and 4,435 new born babies from natural pregnancy in the hospital in 2004 were as the control.
Results： The rates of preterm birth, low birth weight and multifetus were significantly higher in ART group than those conceived spontaneously. The rates of inborn defects and neonatal death were similar in both groups. Prenatal genetic counseling and prenatal diagnosis can diagnose the abnormality of intrauterine fetal growth.
Conclusions. ART infants are the special neonatals, and their perinatal morbllity rate associated with multifetal pregnancies and the need of medical care are increased. Couples seeking for ART should be counseled about the increased risk of adverse outcomes and the prenatal diagnosis should be performed to improve the prognosis of ART pregnancies
出处
《生殖医学杂志》
CAS
2006年第4期241-243,共3页
Journal of Reproductive Medicine
关键词
辅助生殖技术
新生儿
安全性
产前诊断
Assisted reprodutive technology
Infant
Safety
Prenatal diagnosis
