摘要
目的:探讨不同剂量氟伐他丁早期干预治疗对肾病综合征(NS)患者血清C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)水平的影响。方法:59例NS患者随机分为A组(20例,给常规治疗);B组(20例,给常规治疗加氟伐他丁40 mg／d);C组(19例,给常规治疗加氟伐他丁80 mg／d)。NS患者在治疗5 d前后分别测定血清CRP、TNF-α及血脂水平。结果:NS患者的血清CRP、TNF-α水平明显高于对照组(P<0．05);40 mg／d和80 mg／d氟伐他汀治疗5 d后血清CRP及TNF-α水平均有明显下降(均P<0．01),而以80 mg／d氟伐他汀组作用更明显;Pearson相关分析显示:NS患者血清CRP与TNF-α水平呈正相关(r=0．72,P<0．01),CRP和TNF-α与血脂水平不相关。结论:NS患者血清炎症因子水平增高,早期氟伐他汀治疗可降低NS患者的血清CRP和TNF-α水平,且呈剂量依赖性。氟伐他汀的抗炎作用独立于降脂作用之外,早期他汀类药物强化治疗可能使NS患者获益更大。
Objective：To investigate the effects of different doses of fluvastatin on serum levels of C-reactive protein （CRP） and tumour necrosis faetor-α（TNF-α in the nephrotic syndrome （NS）. Methods：59 patients with NS were randomly separated into three groups. 20 patients in group A were given routine therapy, 20 patients in group B were given routine therapy with oral fluvastatin 40mg once daily for 5 days and 19 patients in group C received routine therapy with oral fluvastatin 80 mg once daily for 5 days. The serum levels of CRP and TNF-α before and after therapy were measured with immunoturbidimetric ashy and ELISA method. Results.. The serum levels of CRP and TNF-α in the patients with NS were significantly higher than those in the control group （P〈0. 05）. The serum levels of CRP and TNF-α significantly lowered after one week of therapy in the two fluvastatin treated groups （P〈0. 01 in all）, especially in the 80 nag fluvastatin group, while no significant difference was observed before and after treatment in the routine therapy group. The serum levels of CRP and TNF-α had a significant positive correlation in the patients with NS （r=0. 72, P〈0. （11）, but no relationship were observed between TC, TG, I,DI;C, or HDL-C and CRP or TNF-α by Pearson correlation analysis. Conclusion： The serum levels of inflammatory factors including CRP and TNF-α are increased in patients with NS and early fluvastatin intervention may decease dose-dependently the serum levels of CRP and TNF-a. The anti-inflammatory effect of fluvastatin may be beyond that of lipid lowering, intensive fluvastatin treatment may yield more significant benefits in the patients with NS.
出处
《中国临床医学》
北大核心
2006年第4期629-631,共3页
Chinese Journal of Clinical Medicine
关键词
肾病综合征
C反应蛋白
肿瘤坏死因子
氟伐他汀
Nephrotic syndrome
C-reactive protein
Tumour necrosis factor-α
Fluvastatin
