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二甲双胍和格列吡嗪对胰岛素敏感指数等的影响 被引量:3

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摘要 目的:探讨二甲双胍对2型糖尿病患者胰岛素敏感性的作用。方法:将已确诊的46例2型糖尿病符合胰岛素抵抗临床诊断指标的患者随机分成两组,分别给予口服二甲双胍与格列吡嗪治疗6个月,治疗前后分别检查如下指标:体重指数、血压、空腹血糖、空腹胰岛素、甘油三脂、高密度脂蛋白、胆固醇。结果:用二甲双胍前后胰岛素敏感性指数(ISI)分别为-4.89、-4.54;用格列吡嗪前后分别为-4.90和-4.70;组间和组间用药前后均有显著性差异(P<0.01)。二甲双胍可使血压、血脂、体重指数改善,而格列吡嗪无此作用。结论:二甲双胍和格列吡嗪均可使胰岛素敏感指数升高,而以二甲双胍为甚。
出处 《海南医学院学报》 CAS 2006年第4期336-337,共2页 Journal of Hainan Medical University
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