摘要
目的分析我国燃煤型氟中毒的改灶降氟防治效果及其影响因素,为防治氟中毒提供科学依据。方法计算机检索中文期刊全文数据库、中国生物医学文献数据库、中文科技期刊数据库和中国优秀博士学位论文数据库。检索时间截至2005年12月。同时检索纳入文献的参考文献。居室保温性与改灶降氟防治效果的资料来源于三峡库区监测点。通过制定纳入和排除标准严格筛选相关文献,对研究证据进行质量评价,对燃煤型氟中毒改灶降氟防治效果的相关指标进行相关分析。结果共纳入12篇文献,质量评价结果9篇为C级,3篇为D级。炉灶正常使用下降率与8～12岁氟斑牙、尿氟下降率呈负相关(Pearson相关系数分别为r=–0.87、–0.63,P<0.01、0.05)。氟斑牙下降率和炉灶正常使用下降率与居室保温性能间具相关关系(两个等级相关系数相同,均为r=–1.00,P<0.01)。结论我国改灶降氟防治燃煤型氟中毒效果方面的研究尚缺乏高质量的证据。本研究结果提示对改灶降氟防治燃煤型氟中毒而言,不仅改灶重要,改灶后的正确使用与维护和住房改造提高其保温性也与防治效果有关。
Objectives To analyze the effect of improved oven for defluorination in coal-burning endemic fluorosis areas in China, and to provide evidence for the prevention and control of fluorosis. Methods Electronic databases including CNKI, CBM, VIP and CDMD-D （1989 to 2005）, were searched. We also checked the reference lists of relevant articles. We selected relevant articles according to the predefined inclusion and exclusion criteria. The methodological quality was assessed . Data on room heat preservation and the effect of improved oven for defluorination were collected in the surveillance spots of Three Gorges Reservoir. Correlation analyses were conducted between the improved oven and its effect parameters.
Results Twelve articles of low quality met the selection criteria, of which 9 were graded C and 3 were graded D in terms of the methodological quality. A negative correlation was found between the decreasing rate of normal oven use and the decreasing rate of dental fluorosis as well as of urine fluorine （Pearson correlation coefficient r = 0.87, - 0.63, P〈0.01, 〈0.05, respectively）. Analysis also revealed a positive correlation between room heat preservation and the decreasing rate of dental fluorosis as well as of normal oven use （the two Spearman correlation coefficients and P values were the same： r = 1.00, P〈0.01）.
Conclusion High-quality studies on the effect of improved oven for defluorination in China are not available. Based on the current evidence, the improved oven for defluorination and the correct use, maintenance and house rebuilding for heat preservation may help to prevent fluorosis .
出处
《中国循证医学杂志》
CSCD
2006年第8期600-604,共5页
Chinese Journal of Evidence-based Medicine
关键词
燃煤型氟中毒
改灶降氟
氧中毒预防
循证医学
Coal-burning endemic fluorosis
Improved oven for defluorination
Prevention and control
Evidence-based medicine
