摘要
运用计算机进行基因序列分析在分子生物学研究中起重要作用，已被越来越多地用于研究大量累积的序列数据，获得许多重要发现。对抗人Ｃ１ｑ轻链可变基因（Ｃ１ｑＶ_Ｌ）的分析结果表明：Ｃ１ｑＶＬ属鼠ＩｇＶＫ基因家族，但与其它种属的Ｉｇ基因也显示较高同源性。它的另─个显著特点是与自身抗体编码基因高度同源。研究结果对我们进─步认识抗－Ｃ１ｑ抗体生理、病理作用具有─定价值。
omputer-aided sequence analysis plays an importapt role in molecular biology,which is being used increasingly to study the large volume of rapidly accumulating sequence date In the present work,the light chain variable gene of anti-human C1q(C1qV_L)was analysed by this approach.The results indicated that the C1qVL belongs to VK gene family of mouse immunoglobulin,it also showed a high homology with the V_K gene of other species.Among the similar segments,most are relevant to the variable gene of autoantibody ,suggesting that C1qVL may be interrelated with anti-C1q autoantibody The information is valuable for the understanding of the effect of ant-C1q antibody in the autoimmune.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1996年第5期275-278,共4页
Chinese Journal of Immunology
基金
国家自然科学基金
