摘要
PTEN基因是近年发现的新抑癌基因,目前已经证实其与多种肿瘤的发生发展有密切的关系。在许多肿瘤中都有PTEN基因表达异常,且其表达异常与肿瘤发生发展的生物学行为有一定相关性。胃癌是我国常见的多发性的恶性肿瘤之一,在胃癌组织中PTEN通过多种途径表达降低。PTEN的突变和异常表达与胃癌的发生、发展、浸润、转移显著相关,可能成为检测胃癌的有效指标之一。
Phosphatase and tensin homologue deleted from chromosome ten/mutated in multiple advanced cancer 1/TGF-β- regulated and epithelial cell enriched phosphatasel （PTEN/MMAC1/TEP1）, a new tumor suppressor gene, encodes a dual specific protein-phospholipic phosphatase involved in a variety of signal transduction pathways. Deletions and mutations of this gene were associated with progression and prognosis of many human cancers. Gastric cancer is one of the most prevalent tumor in China . It is demonstrated that PETN might play an important role in carcinogenesis and progression of gastric cancer. It was suggested that PTEN be an effective marker and therapeutic target for gastric cancer.
出处
《山东科学》
CAS
2006年第4期44-48,共5页
Shandong Science
关键词
PTEN抑癌基因
胃癌
异常表达
suppressor PTEN gene
gastric cancer
abnormal expression
